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A First Course in Pharmacokinetics and Biopharmaceutics

Zoom+  Zoom- Publish date: 2014-06-27   Hits: 2229
An online tutorial written by David Bourne, Ph.D. Contents are also available in CD. Content 1. Introduction to Course * Staff * Grading * Coursework * Laboratory Experiments * Textbook * Other References * Journals * 2. Background Material * Exponents * Logarithms * Semi-log graph paper * Calculus * Differential Calculus * Integral Calculus * Spreadsheet Calculations * Spectrophotometric Analysis * 3. Pharmacokinetic Introduction * 4. One Compartment I.V. Bolus * Assumptions * First-order kinetics * Plasma data * Area under the Curve * Half-life * 5. Analysis of Urine Data * Excretion Unchanged - No Metabolism * Metabolism and Excretion - Parallel Pathways * Clearance, CL * 6. Intravenous Infusion * Continuous infusion - steady state * Combined Infusion and bolus administration * Combined slow and fast infusion * Post infusion * 7. Routes of Drug Administration * Oral * Buccal/Sublingual * Rectal * Intravenous * Subcutaneous * Intramuscular * Inhalation * Topical * Other ROA's * 8. Pharmacokinetics of Oral Administration * Differential equation * Integrated equation * Absorption rate constant, ka * Extent of absorption * 9. Calculation of Bioavailability Parameters * Calculation of ka * Calculation of F * 10. Bioavailability Studies * Definitions * Past bioavailability problems * Reasons for bioequivalence requirements * Bioavailability study characteristics * 11. Physiological Factors Affecting Oral Absorption * Membrane physiology * Gastrointestinal physiology * 12. Physical-Chemical Factors Affecting Oral Absorption * pH - partition * Drug dissolution * 13. Formulation Factors * Solutions * Suspensions * Capsules * Tablets * Sustained release tablets * In vitro dosage form testing * 14. Multiple IV Bolus Dose Administration * Single dose summary * IV bolus * IV infusion * Oral administration * Multiple IV bolus * Independent doses * Accumulating doses * Development of general equation * Cpmax and Cpmin equations * 15. Multiple Oral Dose Administration * Cpmin equation * Average Cp equation * Non-uniform dosing intervals * 16. Routes of Excretion * Renal excretion * Hemodialysis * Biliary excretion * Pulmonary excretion * Salivary excretion * Renal disease considerations * Dose adjustment * Average Cp calculations * Cpmax/Cpmin calculations * 17. Metabolism * Metabolic reactions * Phase I * Phase II * Induction * Inhibition * Hepatic clearance * Systemic availability * 18. Drug Distribution * Drug distribution patterns * Factors affecting drug distribution * Rate of distribution * Extent of distribution * Weight considerations * Protein binding interactions * 19. Multi-Compartment Pharmacokinetic Models * Intravenous administration * Scheme or diagram * Differential equation * Integrated equation * Parameter determination * Effect of k12 and k21 * Apparent volumes of distribution * Dosage calculations * Oral administration * Non Compartmental Analysis * 20. Non-Linear Pharmacokinetic Models * Scheme or diagram * Differential equation * Parallel pathway * Dosing approaches * 21. Clinical Applications of Pharmacokinetics * Therapeutic drug monitoring * Pediatric considerations * Geriatric considerations * 22. Laboratory Assignments * Introduction * Analysis of drugs by visible spectroscopy * Extraction of salicylic acid * One compartment model - IV bolus * One compartment model - IV infusion * One compartment model - Oral * Computer simulation - single dose * Student presentation concerning Biopharmaceutics * One compartment model-IV bolus- multiple dose * Computer simulation - multiple dose * Computer simulation - two compartment models * Student presentations on Pharmacokinetics * Pharmacokinetic simulations using MacDope
 
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