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Peptide Epitope Mapping

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Peptide epitope mapping of monoclonalantibodies is a valuable technique thatprovides researchers with the identity of the amino acid residues on a proteinantigen that are recognized by an antibody. Short overlapping peptide sequences takenfrom the known protein sequence are test-ed for binding to the antibody of interest.Once the peptide containing the epitopeis identified, finer epitope mapping withinthis peptide sequence can be performedusing alanine scanning mutagenesis toidentify specific residues important forepitope recognition.(application notes from HTS Biosystems)
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