A method for the generation of YAC transgenic mice by pronuclear microinjection.

Abstract:

Yeast artificial chromosomes (YACs) represent the latest generation of vectors which have the great advantage of large insert size. The introduction of YACs into mammalian cells and organisms has become an important goal, since it offers the potential to

Nucleic Acids Research.1993:21(20):4783

Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg.

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