telomerase RNA component (TERC)
Name: TERC
Description: telomerase RNA component
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 3
GeneticSource: genomic
MapLocation: 3q26
OtherAliases: SCARNA19, TR, TRC3, hTR
OtherDesignations:
NomenclatureSymbol: TERC
NomenclatureName: telomerase RNA component
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 25045
Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia. [provided by RefSeq]
ChrSort: 03
ChrStart: 169482397
UniProtein db: TERC UniProt protein knowledge database
Ensembl db: TERC Ensembl genome database
Complete information for TERC gene (RNA gene), telomerase RNA component
[TERC] Telomerase is a ribonucleoprotein polymerase that maintains ... Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be ...
Human telomerase RNA component (TERC) gene copy numbers, chromosomal instability and HPV integration in premalignant lesions and cancer of the uterine cervix ...
A fluorescence in situ hybridization procedure using a TERC-specific DNA probe was performed on the same specimens and TERC gene copy number was evaluated. ...
... includes concurrent sequence analyses of the TERT and TERC genes. ... in the TERT or TERC genes generally detected by the The Ambry Test: IPF Telomerase except as noted above. ...
Medline Search: cancer AND gene AND (TERC[TI] OR hTR[TI] OR TRC3[TI] ... dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 1997; 14(9):1013-21 ...
This event may be due to our current lack of knowledge of the complete gene structure or an ... Informed Consent for DKC1 and TERC Page 2 of 2 GeneDx 02/09 ...
A) Hybridization of the TERC gene (yellow) to previously stained routine ... TERC gene (yellow) to previously stained routine Pap smears from a patient who ...
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism ... TERC disruption in mice may foster ageing after four normal ...
Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be ... Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by ...
Gene symbol. Chromosomal location. Gene name. Log in. TERC. 3q26. Telomerase RNA component ... Gene Symbol. Chromosomal location. Gene name. Log in. TERC. 3q26 ...
Mouse Terc Chr3:96218360-96218756 bp, - strand has data for genome coordinates, ... Entrez Gene. 21748. International Mouse Knockout Project Status. Terc. References ...
C) Hybridization of the TERC gene (yellow) to previously stained ... D) Hybridization of the TERC gene (yellow) to previously stained routine Pap smears from ...
TERC - telomerase RNA component - Bioportfolio ... TERC siRNA, shRNA and Lentiviral Particle Gene Silencers ... for independent verification of TERC gene silencing results, ...
The TERC gene was increasingly gained with progression of CIN 2/3 (3 of 17) ... In the lesions exhibiting gain of TERC, the virus was predominantly integrated. ...