T-box 21 (TBX21)

Name: TBX21
Description: T-box 21
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 17
GeneticSource: genomic
MapLocation: 17q21.32
OtherAliases: T-PET, T-bet, TBET, TBLYM
OtherDesignations: T-box expressed in T cells|T-cell-specific T-box transcription factor
NomenclatureSymbol: TBX21
NomenclatureName: T-box 21
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 18147
Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]
ChrSort: 17
ChrStart: 45810609

UniProtein db: TBX21 UniProt protein knowledge database
Ensembl db: TBX21 Ensembl genome database

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