sequestosome 1 (SQSTM1)

Name: SQSTM1
Description: sequestosome 1
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 5
GeneticSource: genomic
MapLocation: 5q35
OtherAliases: A170, OSIL, PDB3, ZIP3, p60, p62, p62B
OtherDesignations: EBI3-associated protein p60|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|ubiquitin-binding protein p62
NomenclatureSymbol: SQSTM1
NomenclatureName: sequestosome 1
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 28785
Summary: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]
ChrSort: 05
ChrStart: 179233387

UniProtein db: SQSTM1 UniProt protein knowledge database
Ensembl db: SQSTM1 Ensembl genome database

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