quinolinate phosphoribosyltransferase (QPRT)

Name: QPRT
Description: quinolinate phosphoribosyltransferase
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 16
GeneticSource: genomic
MapLocation: 16p11.2
OtherAliases: QPRTase
OtherDesignations: nicotinate-nucleotide pyrophosphorylase (carboxylating)
NomenclatureSymbol: QPRT
NomenclatureName: quinolinate phosphoribosyltransferase
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 3321
Summary: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer s disease, and Huntington s disease. [provided by RefSeq]
ChrSort: 16
ChrStart: 29690440

UniProtein db: QPRT UniProt protein knowledge database
Ensembl db: QPRT Ensembl genome database

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