patched homolog 2 (Drosophila) (PTCH2)
Name: PTCH2
Description: patched homolog 2 (Drosophila)
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 1
GeneticSource: genomic
MapLocation: 1p33-p34
OtherAliases: RP11-269F19.8, PTC2
OtherDesignations: patched 2
NomenclatureSymbol: PTCH2
NomenclatureName: patched homolog 2 (Drosophila)
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 3778
Summary: This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.
ChrSort: 01
ChrStart: 45288086
UniProtein db: PTCH2 UniProt protein knowledge database
Ensembl db: PTCH2 Ensembl genome database
Complete information for PTCH2 gene (protein-coding), patched homolog 2 (Drosophila)
[PTCH2] This gene encodes a member of the patched gene family. ... This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays ...
Mouse Ptch2 Chr4:116768680-116788706 bp, + strand has data for genome ...
PTCH2, a Novel Human Patched Gene, Undergoing Alternative Splicing ... A BAC clone encompassing the PTCH2 gene was isolated using primers corresponding to the 3' ...
NCBI Summary: This gene encodes a member of the patched gene family. ... Additionally, the PTCH2 gene was found to be a target of HH signalling. ...
features of PTCH2 make this a gene of interest and potentially ... do this, we used gene targeting to remove exons 5 to 17 of the Ptch2. gene, a region that encodes the majority ...
(PTCH2), a putative tumour suppressor gene in. basal cell carcinoma and ... transcript of the PTCH2 gene which ends in intron 11. A. canonical AATAAA polyadenylation ...
The PTCH2 gene encodes a 1,203-amino acid putative transmembrane protein that is ... GENE STRUCTURE Smyth et al. (1999) found that the PTCH2 gene contains 22 coding exons and ...
PTCH2 (patched homolog 2 (Drosophila)), Authors: Peter Zaphiropoulos. Published in: Atlas Genet Cytogenet Oncol Haematol.
Objective: The present study aimed to investigate the pathogenic gene in a Chinese Han NBCCS family. ... used to investigate the candidate genes SHH, PTCH, PTCH2, and SMO. ...
The human PTCH2 gene is highly similar to PTCH1, a tumour suppressor gene frequently mutated in basal cell carcinoma and several other tumour types. ...
Isolation and characterization of human Patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32 ...
Here, we describe the cloning of a second Ptc gene from chick (Ptc2) ... ences imply that the Ptch2 gene in mammals may have. evolved to serve a function distinct ...
Fan, Z; Li, J; Du, J; Zhang, H; Shen, Y; Wang, C-Y; Wang, S ... Methods: Mapping and mutation screening were used to investigate the candidate genes SHH, PTCH, PTCH2 and SMO. ...
The data in COSMIC for PTCH2 is from selected papers only and does not represent a wide survey of publications for this gene. Small Intragenic Mutation Summary ...