period homolog 2 (Drosophila) (PER2)
Name: PER2
Description: period homolog 2 (Drosophila)
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 2
GeneticSource: genomic
MapLocation: 2q37.3
OtherAliases: FASPS, KIAA0347
OtherDesignations: period 2|period circadian protein 2
NomenclatureSymbol: PER2
NomenclatureName: period homolog 2 (Drosophila)
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 10176
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq]
ChrSort: 02
ChrStart: 239152678
UniProtein db: PER2 UniProt protein knowledge database
Ensembl db: PER2 Ensembl genome database
Complete information for PER2 gene (protein-coding), period homolog 2 (Drosophila)
Period circadian protein homolog 2 is a protein that in humans is encoded by the PER2 gene.[1][2] ... Genes in this family encode components of the circadian rhythms of ...
to analyze expression of the human per2 gene in patients. who underwent surgery for ... regulated in the liver of per2 gene deficient mice and, via the ...
Sample user questions on circadian biology for Introduction to Molecular Biology Information Resources ... In my grant proposal, I plan to focus on the human PER2 gene. ...
Recent studies suggested that Per2 behaves as a tumor suppressor gene in mice. ... These results suggest that Per2 is a downstream C/EBPα-target gene involved in AML, and ...
The circadian rhythm is originally generated by a transcription-translation basedoscillatory loop where Per1 and Per2 genes locate in its central. ...
oscillatory loop where Per1 and Per2 genes locate in its central. ... transcription of Per1 and Per2 genes were highly conserved in rats and mice. ...
Cruciani F. Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection. Eur J Hum Genet 16:1526 (2008)
The per2 gene acts in combination with other hereditary factors on the ... Mice with this mutation in the per2 gene drank three times as much alcohol as ...
between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake. ... a difference in gene expression between wild-type and Per2 ...
Per2 mutants. Compared with Per2 mutants, a greater endothelium-dependent relaxation to ... Conclusions—Mutation in the Per2 gene in mice is associated with ...
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function ... Conclusions— Mutation in the Per2 gene in mice is associated with aortic ...
Genetic ablation of the Sirt1 gene or pharmacological inhibition of SIRT1 ... SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation ...
the clock genes Per1 and Per2, similar to that observed. in the SCNs of animals receiving a light pulse [8–10] ... that had little or no effect on immediate early Per2 expres ...
phase delay in Per2 gene oscillation in peripheral tis- compared to what is seen in the wt MEFs, and the ... protection assay (RPA) of Per2 gene expression in serum-shocked (A) ...