PARK2 co-regulated (PACRG)
Name: PACRG
Description: PARK2 co-regulated
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 6
GeneticSource: genomic
MapLocation: 6q26
OtherAliases: hCG_1810756, FLJ32724, GLUP, HAK005771, PARK2CRG, RP3-495O10.2
OtherDesignations: OTTHUMP00000017729|molecular chaperone/chaperonin-binding protein|parkin co-regulated gene protein
NomenclatureSymbol: PACRG
NomenclatureName: PARK2 co-regulated
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 6038
Summary: This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson s disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson s disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
ChrSort: 06
ChrStart: 163148163
UniProtein db: PACRG UniProt protein knowledge database
Ensembl db: PACRG Ensembl genome database
Complete information for PACRG gene (protein-coding), PARK2 co-regulated
Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.[1][2] This gene encodes a protein that is conserved across metazoans. ...
Recently, the PACRG gene product was implicated in the function of flagella. ... Microscopic studies showed that PACRG bundles microtubules and forms branched ...
Deletion of the parkin and PACRG gene promoter in early-onset parkinsonism. ... and the neighboring parkin coregulated gene (PACRG), which are oriented head-to-head and ...
This gene encodes a protein that is conserved across metazoans. ... No NextBio users were found for "PACRG". Complete your user profile with your interests, if you want others ...
( 2004) Susceptibility to leprosy is associated with PARK2 and PACRG, Nature 427, 636-640 ... regulatory region of PARK2 and PACRG genes with leprosy in an Indian population. ...
Parkin-co-regulated gene (PACRG) is a human gene whose transcription is co-regulated with ... However, PACRG does not appear to be a major component of the beaks, since mbo1-3 ...
PACRG was originally identiļ¬ed (West et al., 2003) as a. gene lying upstream of, and ... the reference gene, QM, and then expressed as a percentage of the ...
Lifeclinic International provides information on blood pressure, ... minor changes in the Parkin 2 gene and its neighbor, PACRG, result in an increased susceptibility to leprosy. ...
The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis ...
Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population ...
We have completed a screen of mutations of FMR1, PINK-1 and PACRG genes in over 250 patients with sporadic and familial PD. ...
PACRG is a gene located very close to parkin, in reverse orientation ... Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene. ...
However, double-stranded RNA-induced posttranscriptional gene silencing is unaffected by the hyl1 mutation. ... Pacrg is the mouse homologue of the human PARKIN-coregulated gene ...
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever ... Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination ...