NADPH oxidase 4 (NOX4)
Name: NOX4
Description: NADPH oxidase 4
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 11
GeneticSource: genomic
MapLocation: 11q14.2-q21
OtherAliases: KOX, KOX-1, RENOX
OtherDesignations: kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase
NomenclatureSymbol: NOX4
NomenclatureName: NADPH oxidase 4
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 18719
Summary: This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
ChrSort: 11
ChrStart: 89057520
UniProtein db: NOX4 UniProt protein knowledge database
Ensembl db: NOX4 Ensembl genome database
Complete information for NOX4 gene (protein-coding), NADPH oxidase 4
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene. Oxygen sensing is essential for homeostasis in all aerobic organisms. ...
Human protein-coding gene NOX4. Represented by 90 ESTs from 42 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 199034 - Hs.371036]
NOX4 Mediates Hypoxia-Induced Proliferation of Human Pulmonary Artery ... Conversely, NOX4 silencing does not decrease hypoxic IGFBP-3 gene expression or secreted ...
The CCDS database identifies a core set of human protein coding regions that are consistently annotated by multiple public resources and pass quality tests.
Mouse Nox4 Chr7:94394606-94547220 bp, + strand has data for genome coordinates, ... VEGA Gene Model. OTTMUSG00000021141. International Mouse Knockout ...
Angiogenic Responses Were Inhibited by Nox4 Gene Silencing ... effects of Nox4 gene silencing on the tube formation and wound healing responses in HMECs. ...
Edit this page in Wiki Genes - NOX4 or see Wiki Gene. These cells express two different ... Knockdown and gene transfection studies confirmed that Nox4 requires p22phox for ...
NOX4 mediates hypoxia-induced proliferation of human pulmonary artery ... Conversely, NOX4 silencing does not decrease hypoxic IGFBP-3 gene expression or secreted protein. ...
Alterations in the expression level of the nox4 gene appear to provide an effective means for the regulation of Nox4-based ROS production. ...
The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle ... Biosystems) and a published sequence for the mouse Nox4 gene (Table 1) ...
These findings identified HCV as a regulator of Nox4 gene expression and subsequent ROS production through an autocrine TGF-dependent mechanism. ...
Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2 ... Nox4 expression was markedly correlated with such a gene induction as ...
Conversely, hepatocytes expressing Nox4 shRNA or an inactive dominant negative ... HCV as a regulator of Nox4 gene expression and subsequent ROS production through ...
Embryonic Stem Cell Differentiation into Smooth Muscle Cells is Mediated by Nox4-Produced H2O2 ... Nox4 expression was markedly correlated with such a gene induction as ...