NADPH oxidase 4 (NOX4)

Name: NOX4
Description: NADPH oxidase 4
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 11
GeneticSource: genomic
MapLocation: 11q14.2-q21
OtherAliases: KOX, KOX-1, RENOX
OtherDesignations: kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase
NomenclatureSymbol: NOX4
NomenclatureName: NADPH oxidase 4
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 18719
Summary: This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
ChrSort: 11
ChrStart: 89057520

UniProtein db: NOX4 UniProt protein knowledge database
Ensembl db: NOX4 Ensembl genome database

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