N-acetylneuraminic acid synthase (NANS)
Name: NANS
Description: N-acetylneuraminic acid synthase
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 9
GeneticSource: genomic
MapLocation: 9p24.1-p23
OtherAliases: RP11-404F11.3, SAS
OtherDesignations: N-acetylneuraminic acid phosphate synthase|sialic acid phosphate synthase|sialic acid synthase
NomenclatureSymbol: NANS
NomenclatureName: N-acetylneuraminic acid synthase
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 3207
Summary: This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq]
ChrSort: 09
ChrStart: 100818958
UniProtein db: NANS UniProt protein knowledge database
Ensembl db: NANS Ensembl genome database
Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.[1][2] ... In insect cells, expression of this gene results in Neu5Ac and KDN production. ...
Complete information for NANS gene (protein-coding), N-acetylneuraminic acid synthase
Human protein-coding gene NANS. Represented by 312 ESTs from 174 cDNA libraries. ... Tissues and development stages from this gene's sequences survey gene expression. ...
Mouse protein-coding gene Nans. Represented by 249 ESTs from 102 cDNA libraries. ... Tissues and development stages from this gene's sequences survey gene expression. ...
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