matrix metallopeptidase 8 (neutrophil collagenase) (MMP8)

Name: MMP8
Description: matrix metallopeptidase 8 (neutrophil collagenase)
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 11
GeneticSource: genomic
MapLocation: 11q22.3
OtherAliases: CLG1, HNC, PMNL-CL
OtherDesignations: PMNL collagenase|matrix metalloproteinase 8|matrix metalloproteinase 8 (neutrophil collagenase)
NomenclatureSymbol: MMP8
NomenclatureName: matrix metallopeptidase 8 (neutrophil collagenase)
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 20690
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
ChrSort: 11
ChrStart: 102582525

UniProtein db: MMP8 UniProt protein knowledge database
Ensembl db: MMP8 Ensembl genome database

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