matrix metallopeptidase 8 (neutrophil collagenase) (MMP8)
Name: MMP8
Description: matrix metallopeptidase 8 (neutrophil collagenase)
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 11
GeneticSource: genomic
MapLocation: 11q22.3
OtherAliases: CLG1, HNC, PMNL-CL
OtherDesignations: PMNL collagenase|matrix metalloproteinase 8|matrix metalloproteinase 8 (neutrophil collagenase)
NomenclatureSymbol: MMP8
NomenclatureName: matrix metallopeptidase 8 (neutrophil collagenase)
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 20690
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
ChrSort: 11
ChrStart: 102582525
UniProtein db: MMP8 UniProt protein knowledge database
Ensembl db: MMP8 Ensembl genome database
Complete information for MMP8 gene (protein-coding), matrix metallopeptidase 8 (neutrophil collagenase)
The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[1] [edit] ... a b "Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil ...
The world's first wiki where authorship really matters. Due credit and reputation for ... The gene expression levels of collagen degrading MMPs, i.e. MMP8, MMP13 and ...
Association of MMP8 gene variation with breast cancer prognosis ... We investigated whether MMP8 gene variation was associated with breast cancer metastasis ...
Association of Matrix Metalloproteinase-8 Gene Variation with Breast Cancer Prognosis ... We investigated whether MMP8 gene variation was associated with ...
MMP8 gene in 140 clinically. and pathologically well-characterized breast cancer patients. ... site) in the MMP8 gene promoter, a 968-bp DNA fragment from position ...
The gene, known as matrix metalloproteinase-8 (MMP8), could pave the ... This family of genes has been associated with cancer metastasis, say the study authors. ...
( B) Genomic organization of MMP8 gene encodes three alternatively spliced transcripts. ... the MMP8 gene was a prerequisite for studies of MMP8 promoter ...
SNP linked to Gene MMP8(geneID:4317) Via Contig Annotation ... Total gene model (contig mRNA transcript): 1. mrna. transcript. protein. mrna orientation ...
Polymorphisms in MMP genes may result in changes in the expression of MMPs being ... in the MMP8 gene. In the case of the +17 C/G polymorphism in MMP8, we found that ...
Association of MMP8 gene variation with breast cancer prognosis. J Decock, JR Long, RC Laxton, XO Shu, C Hodgkinson, W Hendrickx, EG Pearce, YT ...
Microarray analysis revealed many novel genes differentially expressed by ventilation including matrix metalloproteinase-8 (MMP8) and GADD45alpha. ...
The gene, known as matrix metalloproteinase-8 (MMP8), could pave the ... This family of genes has been associated with cancer metastasis, said ...
The mmp8 gene was chosen because of its remarkable increase in expression ... We observed increased MMP8 gene and protein expression following mechanical ...
Matrix metalloproteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting ... SNP haplotypes in the MMP8 gene and associations with obstetrical ...