megakaryoblastic leukemia (translocation) 1 (MKL1)
Name: MKL1
Description: megakaryoblastic leukemia (translocation) 1
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 22
GeneticSource: genomic
MapLocation: 22q13
OtherAliases: RP5-1042K10.11, BSAC, MAL, MRTF-A
OtherDesignations: OTTHUMP00000199247|RBM15/MKL1 fusion|RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein|basic, SAP and coiled-coil domain|megakaryoblastic leukemia 1|megakaryoblastic leukemia 1 protein|megakaryocytic acute leukemia|myocardin-related transcription factor A
NomenclatureSymbol: MKL1
NomenclatureName: megakaryoblastic leukemia (translocation) 1
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 7861
Summary: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq]
ChrSort: 22
ChrStart: 40806291
UniProtein db: MKL1 UniProt protein knowledge database
Ensembl db: MKL1 Ensembl genome database
Complete information for MKL1 gene (protein-coding), megakaryoblastic leukemia (translocation) 1
MKL/myocardin-like protein 1 is a protein that in humans is encoded by the MKL1 gene.[1][2][3][4] ... This gene is involved in a specific translocation event that creates ...
A gene that is critical for normal mammary gland function during ... "MKL1 is particularly interesting because it does not appear to be necessary for the normal development of ...
A gene critical for normal mammary gland function during nursing helps trigger highly lethal group leukemias when it undergoes mutation fuses it to another gene
AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on ...
A gene that is critical for normal mammary gland function during nursing helps ... So we were surprised that the loss of the MKL1 gene had such a limited effect. ...
A gene that is critical for normal mammary gland function during ... So we were surprised that the loss of the MKL1 gene had such a limited effect. ...
Acute Myeloid Leukemia-Associated Mkl1 (Mrtf-a) Is a Key Regulator of Mammary Gland Function ... Here we investigate Mkl1 function using gene targeting and show the protein to ...
A gene that is critical for normal mammary gland function during ... "MKL1 is particularly interesting because it does not appear to be necessary for the normal development of ...
It was found that a gene responsible for regulating the normal mammary gland function during nursing can also initiate leukemias. - Page 2
Megakaryoblastic leukemia 1 (MKL1) was originally identified as a gene translocated in megakaryoblastic ... The human MKL1 gene encodes a 931-amino acids protein (Ma et al. ...
NewsRx is the leading source of news and information on Cancer Therapy ... So we were surprised that the loss of the MKL1 gene had such a limited effect. ...
Health,s a group of specific genes that cooperate to perform a particular fun... This MKL1-linked SRF pathway is one of two such cellular signaling ...This probably ...
The MKL1 gene product is a 4.5-kb transcript that is widely expressed in normal ... We used Applied Biosystems TaqMan Gene Expression Assays Mm01207208 and the ...
MKL1 has yet to be included in the public version of HGMD. Mutation data are made freely ... Gene name. Log in. MKL1. 22q13. Megakaryoblastic leukemia (translocation) 1 ...