myelin basic protein (MBP)
Name: MBP
Description: myelin basic protein
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 18
GeneticSource: genomic
MapLocation: 18q23
OtherAliases: MGC99675
OtherDesignations: Golli-mbp|OTTHUMP00000174383
NomenclatureSymbol: MBP
NomenclatureName: myelin basic protein
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 27618
Summary: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP ) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq]
ChrSort: 18
ChrStart: 74690788
UniProtein db: MBP UniProt protein knowledge database
Ensembl db: MBP Ensembl genome database
Real-time quantitative PCR and RT-PCR primer sets for MBP
PATTYN, F., SPELEMAN, F., DE PAEPE A. & VANDESOMPELE, J. (2003). RTPrimerDB: the Real-Time PCR primer and probe database. Nucleic Acids Research, 31(1): 122-123.
Application: MBP Gene Expression Quantification/Detection SYBR Green I PCR
Forward primer: GGCCCCGTGGATGGA
Reverse primer: GAGGCGCGAAAGGAGATG
Probe:
Amplicon:
Annealing temperature: 60
Complete information for MBP gene (protein-coding), myelin basic protein
Human protein-coding gene MBP. Represented by 21704 ESTs from 368 cDNA libraries. ... Tissues and development stages from this gene's sequences survey gene expression. ...
MBP was initially sequenced in 1979 after isolation from myelin membranes [1] ... The gene for MBP is on chromosome 18; the protein localizes to the CNS and to ...
Mouse Mbp Chr18:82644538-82755029 bp, + strand has data for genome coordinates, mammalian orthology, sequences, phenotypes, polymorphisms, SNPs, expression ...
Lecture 5 Reversing the effects of the Shiverer gene (deletion of MBP gene) ... animals with have the MBP gene construct in their germline cells. ...
Gene organization and transcription of duplicated MBP genes of myelin ... In shi(mld), the MBP gene is duplicated and its reduced expression is mainly determined ...
Structure and developmental expression of golli-mbp gene products in Xenopus laevis ... describes systematically the golli-mbp gene products in non-mammalian vertebrates. ...
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. ...
We have previously found evidence for linkage as well as allelic and haplotype association between the myelin basic protein (MBP) gene and multiple sclerosis (MS) ...
The myelin basic protein (MBP) gene produces two families of ... the golli-mbp gene, is 105 kb in mice; its structure and the two. families of products it ...
replacing the mutated MBP gene with the wild type gene. On Thursday we will discuss these ... Is the transcription of other genes altered by mutations in the MBP gene? ...
Early chapters cover the MBP gene, the functions of the golli proteins, and posttranslational modification of MPB. Myelin basic protein by SciTech Book News ...
These mRNAs are transcribed from a region of 3 exons, located upstream of the classic MBP exons, and belong to the long MBP gene otherwise called 'Golli-MBP. ...
Entrez Gene Summary. The protein encoded by the classic MBP gene is a ... However, MBP-related transcripts are also present in the bone marrow and the ...
The wild-type MBP gene has at least two separately regulated functions. ... Some function of the MBP gene may be toxic to oligodendrocytes unless it is ...