myelin basic protein (MBP)

Name: MBP
Description: myelin basic protein
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 18
GeneticSource: genomic
MapLocation: 18q23
OtherAliases: MGC99675
OtherDesignations: Golli-mbp|OTTHUMP00000174383
NomenclatureSymbol: MBP
NomenclatureName: myelin basic protein
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 27618
Summary: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP ) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq]
ChrSort: 18
ChrStart: 74690788

UniProtein db: MBP UniProt protein knowledge database
Ensembl db: MBP Ensembl genome database

Real-time quantitative PCR and RT-PCR primer sets for MBP
PATTYN, F., SPELEMAN, F., DE PAEPE A. & VANDESOMPELE, J. (2003). RTPrimerDB: the Real-Time PCR primer and probe database. Nucleic Acids Research, 31(1): 122-123.

Application: MBP Gene Expression Quantification/Detection SYBR Green I PCR
Forward primer: GGCCCCGTGGATGGA
Reverse primer: GAGGCGCGAAAGGAGATG
Probe:
Amplicon:
Annealing temperature: 60

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