killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 (KIR3DL3)
Name: KIR3DL3
Description: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 19
GeneticSource: genomic
MapLocation: 19q13.42
OtherAliases: CD158Z, KIR3DL7, KIR44, KIRC1
OtherDesignations: killer cell Ig-like receptor KIR3DL7
NomenclatureSymbol: KIR3DL3
NomenclatureName: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 7876
Summary: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. [provided by RefSeq]
ChrSort: 19
ChrStart: 55235983
UniProtein db: KIR3DL3 UniProt protein knowledge database
Ensembl db: KIR3DL3 Ensembl genome database
Complete information for KIR3DL3 gene (protein-coding), killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) ...
Human protein-coding gene KIR3DL3. Corresponds to reference sequence NM_153443.3. [UniGene 2394301 - Hs.645224]
Human gene symbol report page for 'KIR3DL3 - killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3'
KIR3DL3 has only one immunoreceptor tyrosine-based inhibitory motif and lacks ... We conclude that the KIR3DL3 gene is not a pseudogene but encodes a ...
Reporter gene experiments using in vitro methylated 5'UTR constructs indicated ... Although KIR3DL3 is regarded as a nonexpressed KIR gene, the transcriptional ...
To identify regulatory elements involved in KIR gene activation, upstream regions of KIR genes were func ... Although KIR3DL3 is regarded as a nonexpressed KIR gene, the ...
XX AC AJ938056; XX DT 15-APR-2005 (Rel. 83, Created) DT 07-OCT-2008 (Rel. ... DE gene), variant 44b TM1 XX KW killer cell immunoglobulin-like receptor; KIR3DL3 gene. ...
96, Last updated, Version 3) XX DE Homo sapiens cell-line RDP7 KIR3DL3 (KIR3DL3) gene, KIR3DL3*00601variant DE allele, partial cds. XX KW. ...
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 ... Gene function, process, cellular location or interacting partner (as ...
Gene: KIR3DL3. killer cell immunoglobulin-like receptor, three domains, long cytoplasmic ... PharmGKB sets gene boundaries by expanding the mRNA boundaries by no ...
Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex ... genes/alleles in the family indicated that only three KIR genes, KIR3DL3, ...
RESULTS: Framework genes KIR2DL4, KIR3DL2, KIR3DL3, and KIRZ were ... KIR2DL4, KIR3DL2, KIR3DL3 and KIR3DP1 were always present, whereas the frequencies of KIR2DL1, KIR2DL3, ...
Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population ... The KIR2DL4, KIR3DL2, KIR3DL3 framework genes were found in all ...
PLoS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. ... The two boundary genes of the KIR cluster, KIR3DL3 and KIR3DL2, and the ...