killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 (KIR3DL3)

Name: KIR3DL3
Description: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 19
GeneticSource: genomic
MapLocation: 19q13.42
OtherAliases: CD158Z, KIR3DL7, KIR44, KIRC1
OtherDesignations: killer cell Ig-like receptor KIR3DL7
NomenclatureSymbol: KIR3DL3
NomenclatureName: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 7876
Summary: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. [provided by RefSeq]
ChrSort: 19
ChrStart: 55235983

UniProtein db: KIR3DL3 UniProt protein knowledge database
Ensembl db: KIR3DL3 Ensembl genome database

KIR3DL3 news
Related resources on KIR3DL3