histone deacetylase 3 (HDAC3)

Name: HDAC3
Description: histone deacetylase 3
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 5
GeneticSource: genomic
MapLocation: 5q31
OtherAliases: HD3, RPD3, RPD3-2
NomenclatureSymbol: HDAC3
NomenclatureName: histone deacetylase 3
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 24629
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq]
ChrSort: 05
ChrStart: 141000442

UniProtein db: HDAC3 UniProt protein knowledge database
Ensembl db: HDAC3 Ensembl genome database

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