GRB2-associated binding protein 1 (GAB1)
Name: GAB1
Description: GRB2-associated binding protein 1
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 4
GeneticSource: genomic
MapLocation: 4q31.21
OtherAliases:
OtherDesignations:
NomenclatureSymbol: GAB1
NomenclatureName: GRB2-associated binding protein 1
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 15947
Summary: The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
ChrSort: 04
ChrStart: 144257982
UniProtein db: GAB1 UniProt protein knowledge database
Ensembl db: GAB1 Ensembl genome database
Complete information for GAB1 gene (protein-coding), GRB2-associated binding protein 1
GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.[1] The protein encoded by this gene is a member of ...
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Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat. ... The Gab1 gene was localized to chromosome 4q31.1 in human, 8C3 in mouse and ...
However, the gene-gene interaction between PTPN11 and Gab1 was not ... Conclusions: This study represents that the Gab1 polymorphism was associated with the low ...
The gene-gene interaction between PTPN11 and Gab1 was also evaluated. ... However, the gene-gene interaction between the PTPN11and the Gab1 was not ...
The essential GAB1 gene, which encodes an endoplasmic reticulum (ER)-membrane ... GAB1 Is an Essential Gene and Encodes a Conserved Protein with Multiple Transmembrane Domains ...
Figure 1 Outline of the strategy used to disrupt the Gab1 gene. ... Ablation of the Gab1 gene in mice results in phenotypes that resemble those of mice ...
We stimulated wild-type mouse embryo fibroblasts (MEF) or. MEF with a homozygous deletion of the Gab1 gene ... mice and developed fibroblasts deficient for the Gab1 gene ...
Genes showing significant differences in epxression between normal and PD¡ ̄s SN. ... Gene regulation - MicroRNAs elements associated with GAB1 regulation: ...
Gab1 has a structure that is similar to other proteins in a family known as ... gene deletion, to create a mouse in which the Gab1 gene was deleted, or "knocked ...
A restriction map of the first three exons of the Gab1 gene (top), the replacement targeting vector (middle), and a map of the locus after homologous ...
Consistent with these results, the Gab1 gene was expressed in marginal zone B cells but not follicular B cells. ... Gab1 in MZ B cells because 1) the Gab1 gene was specifically ...
Targeted disruption of the mouse Gab1 gene revealed that Gab1 is essential for development of the heart, ... Because Gab1 gene expression was detected in pre-B cells of the bone ...
GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. ... The Grb2-associated binder 1 (Gab1), which serves as a scaffolding adaptor ...