dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (DUSP11)

Name: DUSP11
Description: dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 2
GeneticSource: genomic
MapLocation: 2p13.1
OtherAliases: PIR1
OtherDesignations: RNA/RNP complex-interacting phosphatase|dual specificity phosphatase 11|serine/threonine specific protein phosphatase
NomenclatureSymbol: DUSP11
NomenclatureName: dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 2020
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq]
ChrSort: 02
ChrStart: 73989324

UniProtein db: DUSP11 UniProt protein knowledge database
Ensembl db: DUSP11 Ensembl genome database

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