discoidin domain receptor tyrosine kinase 2 (DDR2)

Name: DDR2
Description: discoidin domain receptor tyrosine kinase 2
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 1
GeneticSource: genomic
MapLocation: 1q23.3
OtherAliases: RP11-572K18.1, MIG20a, NTRKR3, TKT, TYRO10
OtherDesignations: cell migration-inducing protein 20|discoidin domain receptor family, member 2|hydroxyaryl-protein kinase|migration-inducing gene 16 protein|neurotrophic tyrosine kinase receptor related 3|tyrosylprotein kinase
NomenclatureSymbol: DDR2
NomenclatureName: discoidin domain receptor tyrosine kinase 2
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 6538
Summary: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq]
ChrSort: 01
ChrStart: 162602227

UniProtein db: DDR2 UniProt protein knowledge database
Ensembl db: DDR2 Ensembl genome database

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