bone morphogenetic protein receptor, type IA (BMPR1A)

Name: BMPR1A
Description: bone morphogenetic protein receptor, type IA
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 10
GeneticSource: genomic
MapLocation: 10q22.3
OtherAliases: 10q23del, ACVRLK3, ALK3, CD292, SKR5
OtherDesignations: OTTHUMP00000020014|activin A receptor, type II-like kinase 3|serine/threonine-protein kinase receptor R5
NomenclatureSymbol: BMPR1A
NomenclatureName: bone morphogenetic protein receptor, type IA
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 15904
Summary: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq]
ChrSort: 10
ChrStart: 88516395

UniProtein db: BMPR1A UniProt protein knowledge database
Ensembl db: BMPR1A Ensembl genome database

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