HLA-B associated transcript 1 (BAT1)
Name: BAT1
Description: HLA-B associated transcript 1
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 6
GeneticSource: genomic
MapLocation: 6p21.3
OtherAliases: DAAP-97M17.4, D6S81E, DDX39B, UAP56
OtherDesignations: 56 kDa U2AF65-associated protein|ATP-dependent RNA helicase p47|DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B|DEAD-box protein UAP56|OTTHUMP00000029228|nuclear RNA helicase (DEAD family)|spliceosome RNA helicase BAT1
NomenclatureSymbol: BAT1
NomenclatureName: HLA-B associated transcript 1
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 10376
Summary: This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
ChrSort: 06
ChrStart: 31497995
UniProtein db: BAT1 UniProt protein knowledge database
Ensembl db: BAT1 Ensembl genome database
Complete information for BAT1 gene (protein-coding), HLA-B associated transcript 1
These genes are all within the human major histocompatibility complex class III region. ... The central MHC gene, BAT1, may encode a protein that down-regulates ...
The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear ... The BAT1 gene has previously been identified about 30 kb upstream from the tumor ...
The BAT1 gene (D6S81E) encodes a member of the DEAD-box family of RNA-binding proteins, ... This region contains genes which affect susceptibility to immunopathological diseases. ...
BAT1 protein may be directly responsible for the genetic association, as ... Lower reporter gene expression for the 520 bp BAT1 promoter fragment from the ...
The protein encoded by this gene is a member of the DEAD protein family of ATP-dependent RNA helicases. ... genes, BAT1-BAT5, has been localized in the vicinity of the genes for ...
BAT1 is the human homolog of the rat p47 nuclear protein, the WM6 ... Polymorphisms in the promoter of the BAT1 gene affect transcription and the binding of ...
Click here for the function of BAT1. Edit this page in Wiki Genes - BAT1 or see Wiki Gene. ... The central MHC gene, BAT1, may encode a protein that down-regulates ...
Alleles of the proximal promoter of BAT1, a putative anti-inflammatory gene adjacent to the TNF cluster, reduce transcription on a disease-associated MHC haplotype ...
of a second RA-susceptibility gene within the telomeric human leukocyte antigen ... ATP6G, and BAT1 genes—namely all of their promoter/ enhancer regions, all of their exons, ...
The LGALS2-A SNP in the gene for galectin-2 was not detectably associated with ... in the promoter of the BAT1 gene affect transcription and the binding ...
Characterisation of the Human Central MHC Gene, BAT1: Genomic Structure and Expression ... This region contains genes which affect susceptibility to immunopathological diseases. ...
BAT1 transcription on the 7.1 AH (diabetes-resistant ancestral haplotype)is ... The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear ...
Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene.[1][2][3] ... Mutations in this gene may be associated with rheumatoid arthritis. ...
"The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear ... Human chromosome 6: entries, gene names and cross-references to MIM ...