BCL2-associated athanogene 3 (BAG3)

Name: BAG3
Description: BCL2-associated athanogene 3
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 10
GeneticSource: genomic
MapLocation: 10q25.2-q26.2
OtherAliases: BAG-3, BIS, CAIR-1, MGC104307
OtherDesignations: BAG-family molecular chaperone regulator-3|BCL2-binding athanogene 3|Bcl-2-binding protein|docking protein CAIR-1
NomenclatureSymbol: BAG3
NomenclatureName: BCL2-associated athanogene 3
NomenclatureStatus: Official
TaxID: 9606
GeneWeight: 9915
Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq]
ChrSort: 10
ChrStart: 121410881

UniProtein db: BAG3 UniProt protein knowledge database
Ensembl db: BAG3 Ensembl genome database

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