BCL2-associated athanogene 3 (BAG3)
Name: BAG3
Description: BCL2-associated athanogene 3
Orgname: Homo sapiens
Status: 0
CurrentID: 0
Chromosome: 10
GeneticSource: genomic
MapLocation: 10q25.2-q26.2
OtherAliases: BAG-3, BIS, CAIR-1, MGC104307
OtherDesignations: BAG-family molecular chaperone regulator-3|BCL2-binding athanogene 3|Bcl-2-binding protein|docking protein CAIR-1
NomenclatureSymbol: BAG3
NomenclatureName: BCL2-associated athanogene 3
NomenclatureStatus: Official
TaxID: 9606
Mim:
GenomicInfo:
GeneWeight: 9915
Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq]
ChrSort: 10
ChrStart: 121410881
UniProtein db: BAG3 UniProt protein knowledge database
Ensembl db: BAG3 Ensembl genome database
Complete information for BAG3 gene (protein-coding), BCL2-associated athanogene 3
Expression of BAG3 is enhanced by a variety of stress-inducing agents. ... Autoactivation of the BAG3 gene is observed in several cultures of human glial ...
BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene.[1][2][3] ... The protein encoded by this gene contains a WW domain in the ...
AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on ...
BAG3 protein is constitutively expressed in muscle and a few other normal cell ... Expression of BAG3 gene in leukaemic cell samples from a study on 24 ...
BAG3-deficient animals developed a fulminant myopathy characterized by noninflammatory ... The bag3 gene, however, is expressed in muscle at this and earlier ...
HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to ... Autoregulation of co-chaperone BAG3 gene transcription. The Bcl-2-associated athanogene, ...
BAG3. Includes Interact, Terminal, Alamat Kantor Akuntan, Akuntan Di, ... The protein encoded by this gene contains a WW domain in the N-terminal region ...
Recently, we generated bag3 gene deletion mice, which showed early ... BAG3 over-expression has been observed in human cancers and regulates cell motility in vitro and in vivo. ...
Transcript: BAG3-002. Transcript-based displays. Transcript summary ... is a product of gene ENSG00000151929 - There are 2 transcripts in this gene: ...
Gene expression in the mouse brain for the gene Bag3, also known as 'Bcl2-associated athanogene 3'
Reporter gene assay identified strong promoter activity in various cell types. ... Autoactivation of the BAG3 gene is observed in several cultures of ...
Histogram - Click for a histogram of the full gene sequence and mutation details. ... Publications - Click for a complete list of curated publications for BAG3 ...
Cell death and differentiation is a monthly research journal focused on the exciting ... we detected the expression of BAG3 gene in leukaemic cell samples from B-CLL ...
Examine the GO annotations for BAG3, using the links above, and tell ... GO curators are notified when particular gene pages are changed and will act upon your ...