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Position: Discussion forums > Bioscience biotechniques discussion forums > Cell biology and histology methods forum
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about "growth-arrested cells"
Posted by: Rosalind324 (IP Hidden, New member, 9)
Date: May 14, 2006 11:55PM
what's "growth-arrested cells"?
and what's difference between "growth-arrested cells" and "growing cancer cells"? Thanks in advice! I appreciate it very much.
Re: about "growth-arrested cells"
Posted by: fatboym (IP Hidden, Junior member, 20)
Date: May 15, 2006 01:09AM
Growth arrested are cells that their cell cycle progression has stopped at a point of this cycle. Either a checkpoint has been activated and hinders the progression of the cell, either they are normal cells and they appear contact inhibition or the cells have entered a terminate proliferative state called senescence and they can no more divide.
On contrary the cance rgrwoing cells, denotes nothing else than cancerous cells that keep dividing. Just cancer cells have no contact inhbition and they can divide despite the unfavorite environmental conditions
Re: about "growth-arrested cells"
Posted by: dkhurtado (IP Hidden, New member, 5)
Date: June 7, 2006 01:09PM
Maybe you are asking about division-arrest? This is a treatment with antibiotics that puts cells in a growth arrest in the mid-log phase so the screening time can be increased in drug discovery processes.
A receptor target can be screened for activity for up to 30 hours and then it starts losing expression. Growth arresting "freezes" ( not temperature) the cells in mid-log phase, so they can be screened for up to 72 hours, which aids greatly in drug discovery.
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