Primer-Extension Preamplified DNA Is a Reliable Template for Genotyping

A open access technical article on genotyping based on primer extension amplifed DNA template.

Clinical Chemistry 48: 1601-1603, 2002

Primer-Extension Preamplified DNA Is a Reliable Template for Genotyping
Helena Kuivaniemi1,2, Sungpil Yoon1, Hidenori Shibamura1, Magdalena Skunca1, Sompong Vongpunsawad1 and Gerard Tromp1a

1 Center for Molecular Medicine and Genetics and
2 Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201-1928

A common constraint faced by genetic studies is the limited amount of DNA available from study participants. It is often not practical or possible to either collect a large amount of tissue such as liver or blood from individuals or to ask for a second sample, particularly if the critical individuals died since the first sample was taken.

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