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The Latest Malaria Vaccine Breakthrough
Submitted on: 2015-03-24        Hits: 714        Return to list
Australian researchers recently have made a significant discovery about how the human body's immune system fights the infection. The discovery could help in the global battle to develop a vaccine for malaria, one of the world's leading killers. 
 
A vaccine for malaria is a step closer to reality after the breakthrough by researchers at the Melbourne-based Burnet Institute.Those Australian researchers have recently identified a response the body uses to protect itself against malaria and they believe this discovery could help in the development of a vaccine for the disease.
 
Professor James Beeson from the Burnet Institute said although malaria was transmitted by mosquitoes, but it would became harmful to human only when the body's red blood cells were infected, which means there is a possible way of preventing malaria if scientist can find a way to prevent the infection of red blood cells.
 
He said the researchers had identified the body's immune system needed both antibodies and other proteins in the bloodstream to fight off malaria in what he called a "double-hit" effect.
 
"The immune system needs to produce specific antibodies and they're proteins that the immune system produces that combat infections," he said.
 
They found the immune system can recruit proteins found in the bloodstream to help prevent malaria parasites from infecting red blood cells. Without this assistance, antibodies alone are often unable to fend off the disease.
 
He explained that the antibodies and the complement together would perform a double hit on the malaria infection and stop it from getting inside red blood cells, and therefore stopping the infection and the subsequent disease.
 
It is estimated that malaria causes up to 600,000 deaths each year, largely among children in Africa. A number of malaria vaccines have been trialled over the years. Many scientists in the past  attempted to develop a malaria vaccine, but they were unsuccessful in part because of the way the parasite can sabotage the immune system and compromise the body's resistance against the infection.  
 
In a vaccine trial of 30 volunteers in Queensland, Professor Beeson's team found the response could be generated so the immune system and the proteins, known as complement, worked together. But according to Beeson, more work is needed to be done to understand how the immune system and complement proteins targeted malaria parasites and how to best trigger and strengthen this response through vaccination.
 
About Malaria
 
Malaria is a serious and fatal global disease caused by parasites that commonly infects a certain type of mosquito which feeds on humans and therefore infecting humans. Malaria occurs mostly in poor tropical and subtropical areas of the world. In many of the countries affected by malaria, it is a leading cause of illness and death. In areas with high transmission, the most vulnerable groups are young children and pregnant women with low immunity. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. Although malaria can be a deadly disease, illness and death from malaria can usually be prevented. 
 
About Creative Diagnostics
 
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components and critical assay reagents. Diagnosis of malaria is a very critical step in malaria researches. Creative Diagnostics can provide several types of Malaria ELISA Kits for research use.
 
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