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| Cell signaling (signaling pathway) is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. |
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Methods in Signal Transduction
new recommended
protocol
An excellent signaling pathway methods and techniques lab course. (Prof. Rony Seger, Department of Biological Regulation at Weizmann institute)
Content:
1) Introduction............................................................................... ...
Cell signalling pathway gateway
new recommended
site
This is a public domain web site specifically focusing on cell signalling pathway. (Nature publishing group).
"The Signaling Gateway, a comprehensive and free online resource that is the result of a collaboration between the Alliance for Cellular Signaling ...
Signal transduction society (STS)
site
Signal Transduction Society (STS) is devoted to scientific exchange between investigators concerned with cellular signal transduction. This is a online community for researchers working on signal transduction. The web site also features job posts, forum and ot ...
Pathguide: The Pathway Resource List
new
site
Pathguide contains information about 197 biological pathway resources. (Robert Hoffmann, PhD, Memorial Sloan-Kettering Cancer Center, MSKCC)
Protein-Protein Interactions
Metabolic Pathways
Signaling Pathways
Pathway Diagrams
Transcription Factors / Gene ...
Interactive graphic models of molecular signaling pathways
troubleshooting
An excellent graphic models of molecular and cellular pathways from biocarta. All graphic models are contributed by researchers in pathway field. You can even download the freehand template to build your own high quality pathway models. Current several categor ...
Cell signaling transduction pathways database
recommended
database
Science's stke (Signal Transduction Knowledge Environment) database for cell signaling pathways.
You can browse the db:
By Subject
By Scope
By Model Organism
By Science Issue ...
Molecular pathway interaction database
new recommended
database
National cancer institute center for bioinformatics (NCICB) developed this pathway interaction database as part of cancer molecular analysis project. Currently it contains 5,000 interactions, 2200 proteins, 350 complexes and 2300 small molecules derived from 9 ...
PANTHER Pathway Tool and Database
new
database
PANTHER Pathway consists of over 60, primarily signaling, pathways, each with subfamilies and protein sequences mapped to individual pathway components. A component is usually a single protein in a given organism, but multiple proteins can ...
CellDesigner: free biochemical signalling pathway network modeling tool
new
software
CellDesignerTM is a modeling tool of biochemical networks with graphical user interface. It is designed to be SBW (Systems Biology Workbench) compliant, and support SBML (Systems Biology Markup Language) format and can be used to model signal transduction path ...
Reactome - a knowledgebase of biological processes and signaling pathway
software
Reactome is a curated database of biological processes in humans. It covers biological pathways ranging from the basic processes of metabolism to high-level processes such as hormonal signalling transduction pathway. While Reactome is targeted at human pathw ...
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Last update:  09-May-2008 05:48 pm
Related new papers and reviews
Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells. Regul Pept. 2008 Jan 10;145(1-3):42-8
Authors: Moriyuki K, Nagataki M, Sekiguchi F, Nishikawa H, Kawabata A
Proteinase-activated receptor-2 (PAR2) plays a dual role in the respiratory system, being pro- and anti-inflammatory. In human lung epithelial cells (A549), PAR2 activation causes release of interleukin-8 (IL-8) in addition to prostaglandin E(2) (PGE(2)). In the present study, we thus investigated PAR2-triggered signal transduction pathways causing IL-8 formation in A549 cells. SLIGRL-NH(2), a PAR2-activating peptide, but not LSIGRL-NH(2), a scrambled peptide, elicited release of IL-8 from A549 cells for 18 h, as measured by the ELISA method, an effect being suppressed by inhibitors of MEK, JNK, EGF receptor-tyrosine kinase (EGFR-TK), Src, pan-tyrosine kinases and protein kinase C, but not p38 MAP kinase or cyclooxygenase. SLIGRL-NH(2) also up-regulated IL-8 at protein and mRNA levels, as determined by Western blotting and RT-PCR, respectively. The PAR2-triggered up-regulation of IL-8 protein and mRNA was blocked by an inhibitor of MEK, but not clearly by inhibitors of JNK and EGFR-TK. SLIGRL-NH(2) actually phosphorylated JNK as well as ERK, the JNK activation being resistant to inhibitors of Src, pan-tyrosine kinases, protein kinase C and EGFR-TK. Our data suggest that PAR2-triggered IL-8 formation involves transcriptional up-regulation of IL-8 via the MEK-ERK pathway, while the JNK and EGF receptor pathways might rather contribute to a post-transcriptional process for the release of IL-8.
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