The United States has the first and the farthest-reaching newborn genetic screening program in the world. Originally intended to rule out genetic disorders in infants, the program is now under pressure to make use of advanced technologies and new medical knowledge to screen for adult-onset conditions, identify trait carriers, and evaluate genetic predispositions to disease. The contributors to this provocative collection study the impact of these changes on the program and offer guidance to professionals, policymakers, and the general public. Experts from the fields of bioethics, genetics, pediatrics, public health, health policy, law, and political science identify and analyze four social and ethical issues critical to newborn screening policy: the distribution of costs and benefits; information, consent, and privacy; consultation and decision making; and race, ethnicity, and socioeconomic status. In the process, the contributors capture the difficulties of trying to forge ethical public policy at the intersection of parental concerns, new technologies, and economic interests.Contributors: Andrea Bonnicksen, Ph.D., Northern Illinois University; Jeffrey R. Botkin, M.D., M.P.H., University of Utah; Ned Calonge, M.D., M.P.H., Department of Public Health and Environment, Denver; Toby Citrin, J.D., University of Michigan School of Public Health; Ellen Wright Clayton, M.D., M.S., J.D., Vanderbilt University; Jannine De Mars Cody, Ph.D., University of Texas Health Science Center; Anne Marie Comeau, Ph.D., University of Massachusetts Medical School; James R. Eckman, M.D., Emory University School of Medicine; Scott D. Grosse, Ph.D., National Center on Birth Defects and Developmental Disabilities; Bruce Jennings, M.A., Yale School of Public Health; Donna E. Levin, J.D., Massachusetts Department of Public Health; Michele A. Lloyd-Puryear, M.D., Ph.D., U.S. Department of Health and Human Services; Marie Y. Mann, M.D., M.P.H., U.S. Department of Health and Human Services; Karen J. Maschke, Ph.D., The Hastings Center; Stephen M. Modell, M.D., M.S., University of Michigan School of Public Health; Virginia A. Moyer, M.D., M.P.H., Baylor College of Medicine and Texas Children's Hospital; Lainie Friedman Ross, M.D., Ph.D., University of Chicago; Joseph Telfair, Dr.P.H., M.S.W., M.P.H., University of North Carolina at Greensboro; Steven M. Teutsch, M.D., M.P.H., Merck & Co., Inc.; Bradford L. Therrell, Ph.D., University of Texas Health Science Center; Benjamin S. Wilfond, M.D., University of Washington
Univ. of Southern California, Los Angeles. Focuses on methods of identifying the joint effects of genes and environment on disease patterns. Features the study designs and statistical analysis techniques for determining whether a trait runs in families, estimating the parameters of genetic model, or whether a genetic tendency is due to genetic or environmental factors.
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A Primer of Population Genetics by: Daniel L. Hartl publisher: Sinauer Associates, published: 2000-01-15 ISBN: 0878933042 sales rank: 383429
Product Description
In response to many requests, the Third Edition of A Primer of Population Genetics has been dramatically shortened and streamlined for greater accessibility. Designed primarily for undergraduates, it will also serve for graduate students and professionals in biology and other sciences who desire a concise but comprehensive overview of the field with a primary focus on the integration of experimental results with theory. The abundance of experimental data generated by the use of molecular methods to study genetic polymorphisms sparked a transformation in the field of population genetics. Present in virtually all organisms, molecular polymorphisms allow populations to be studied without regard to species or habitat, and without the need for controlled crosses, mutant genes, or for any prior genetic studies. Thus a familiarity with population genetics has become essential for any biologist whose work is at the population level. These fields include evolution, ecology, systematics, plant breeding, animal breeding, conservation and wildlife management, human genetics, and anthropology. Population genetics seeks to understand the causes of genetic differences within and among species, and molecular biology provides a rich repertoire of techniques for identifying these differences. The book is organized as a user's guide to population genetics. Chapter 1 starts with the basic concepts of molecular genetics and examines the principal methods by which DNA (or proteins) can be manipulated to reveal genetic polymorphisms in any population. Chapter 1 also includes the principles of population genetics underlying the organization of genetic variation in populations, with special emphasis on random mating, linkage equilibrium and disequilibrium, and inbreeding. Chapter 2 examines the evolutionary processes that can change allele frequencies, including mutation, migration and population admixture, natural selection of various types, and random genetic drift. This chapter also includes an elementary explanation of the diffusion equations as used in population genetics. Chapter 3 is the core of molecular population genetics. It includes the analysis of nucleotide polymorphism and diversity based on coalescents, patterns of change in nucleotide and amino acid sequences with special emphasis on codon usage bias and amino acid polymorphisms, inferences based on comparisons of levels of polymorphism and divergence, molecular phylogenetics, and the population dynamics of transposable elements. Chapter 4 focuses on complex traits whose expression is influenced by multiple genes and environmental factors. It examines genetic effects on the components of phenotypic variation and the correlations between relatives, the evolution of quantitative traits in natural populations, and comes full circle with the use of molecular polymorphisms and candidate genes in the identification of quantitative trait loci underlying complex inheritance. As for mathematical rigor, while there are some equations, the emphasis is on explanation rather than derivation. Only elementary algebra is necessary to follow most of the material, but a familiarity with basic calculus is helpful for understanding diffusion equations, Poisson random fields, and complex threshold traits. Mathematical symbols are used consistently throughout the book, and when results from the theoretical literature are quoted, the original symbols have been changed as necessary to maintain consistency. Modern population genetics makes liberal use of acronyms-these are all defined in the text, and their interrelations and implications are discussed. For ease of reference there is a glossary of acronyms and other common abbreviations used in population genetics. The text also includes numerous practical examples showing how the theoretical concepts are applied to actual data, as well as chapter-end problems.
The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links
Review
This latest textbook in population genetics flies above and beyond any other textbook I've read in the field because of its clarity and depth of coverage.
Templeton offers new and unique insights in several key topics in population genetics, and he gives plenty of caveats throughout where important population genetics concepts have been misunderstood. For example, his coverage of inbreeding cofficients is exceptional, and he rightly points out how different inbreeding coefficients are wrongly used in the literature. His approach throughout is multi-dimentional, encompassing the interaction between different evolutionary forces and always stressing the prime importance of population history. A very thorough discussion on the use of linkage disequilibrium in medical genetics is also included.
Does this book have any weak points? It's hard to point out any, such was my overall highly positive impression from reading the book.
Templeton's scholarship is vast and deep, as is his publication record. The unique perspectives offered by this book certainly puts it among the best science books I own.
Population genetics is concerned with the origin, amount, and distribution of genetic variation present in populations of organisms and the fate of this variation through space and time. As such it is dealing with the mechanisms by which evolution occurs within populations and species, the ultimate basis for all evolutionary change.
It is not a new science, but like the rest of biology has seen significant change occurring as problems of species extinction and environmental degradation became important to students of conservation biology, and as the analytical methods developed for population genetics have been found to be useful in many areas of genomics.
This book provides a basic foundation in population genetics for advanced undergraduates and graduate students. While the book is not primarily mathematical in its approach, the student should have at least a beginning understanding of calculus.
Dr. Templeton is the Charles Rebstock Professor of Biology at Washington University in St. Louis with joint appointments in Genetics and Biomedical Engineering.
Establishing genetics as a top priority for clinicians. A revolution has occurred in the practice of medicine that will have a profound effect on the family. Here, a stellar group of mental health practitioners assess the impact of genetic knowledge on family life in such areas as: genetic screening and testing; legal and ethical issues; infertility; informed decision making; and the current understanding of various genetic conditions.
Ever since scientists first cloned Dolly, genetics has been a hot-button topic in the media and the political world. Genetics brings readers the inside story, and looks objectively at this fascinating modern science. From the Human Genome Project to stem cell research to the National Geographic?s own Genographic Project, scientists are exploring and rapidly advancing our knowledge of the human condition.
"Genetics: From Genes to Genomes" is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Third Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.
Review This international edition is exactly what I needed and for a great price. It is much cheaper than it's American counterpart, which is a hard back. The only downside is that the page edges will bend if you aren't careful, but other than that, it is an amazing intro to Genetics book if you need one.
This is a very great textbook for undergraduate genetics!
Definitely a classic for your collection.
Easy Outline of Genetics by: William Stansfield publisher: McGraw-Hill, published: 2002-02-26 ISBN: 0071383174 sales rank: 287099
Product Description
Boiled-down essentials of the top-selling Schaum's Outline series for the student with limited time What could be better than the bestselling Schaum's Outline series? For students looking for a quick nuts-and-bolts overview, it would have to be Schaum's Easy Outline series. Every book in this series is a pared-down, simplified, and tightly focused version of its predecessor. With an emphasis on clarity and brevity, each new title features a streamlined and updated format and the absolute essence of the subject, presented in a concise and readily understandable form. Graphic elements such as sidebars, reader-alert icons, and boxed highlights stress selected points from the text, illuminate keys to learning, and give students quick pointers to the essentials. Designed to appeal to underprepared students and readers turned off by dense text Cartoons, sidebars, icons, and other graphic pointers get the material across fast Concise text focuses on the essence of the subject Delivers expert help from teachers who are authorities in their fields Perfect for last-minute test preparation So small and light that they fit in a backpack!
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Principles of Medical Genetics by: Thomas D., M.D. Gelehrter, Francis S. Collins, David Ginsburg publisher: Lippincott Williams & Wilkins, published: 1998-01-15 ISBN: 0683034456 sales rank: 335996
Product Description
Univ. of Michigan Medical School, Ann Arbor. Brandon/Hill Medical List minimal-core and firstpurchase selection (#203). New to this edition: triplet repeat disease and discussions on sex. Previous edition: c1990. Softcover. DNLM: Genetics, Medical.