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By: DESH PAL S., ED. VERMA
ISBN: 3211827455
Publisher: SPRINGER-VERLAG
Release Date: 1996
Bioscience book rank: 5914954
By: Carl-Henrik Heldin, Mary Purton
ISBN: 0412708108
Publisher: International Thomson Publishing Services
Release Date: December, 1996
Bioscience book rank: 3086445
I am a graduate student and I obtained this book one week before my final exam for a one-semester course on signal transduction. The concise text and clear layout of this book helped me a great deal in reviewing the key concepts of this enormous research field. THis book is an excellent guide for students as well as for those aiming for advanced learning.

This book is a comprehensive guide to signal transduction. It provides an in depth overview of all the major mechanisms, with tips for further reading. This is an invaluable aid to all studying at advanced Degree level, or higher (Ph.D).
By: J.A. Barnes, H.G. Coore, Abdul H. Mohammed, Rajendra K. Sharma
ISBN: 0792336631
Publisher: Springer
Release Date: 30 September, 1997
Bioscience book rank:
By: Ryutaro Utsumi
ISBN: 0387788840
Publisher: Springer
Release Date: May, 2008
Bioscience book rank:
By: A.R. Smith, A.W. Berry, N.V.J. Harpham, I.E. Moshkov, G.V. Novikova, O.N. Kulaeva, M.A. Hall
ISBN: 0792337689
Publisher: Springer
Release Date: 31 July, 1996
Bioscience book rank: 6106872
By: HIROKI, ED. OZAWA
ISBN: 4431702105
Publisher: SPRINGER-VERLAG
Release Date: 1998
Bioscience book rank: 4197928
I read 41 different books (and over 500 journal articles) in preparing my new book, The Failures of American Medicine. All of the other books that I have reviewed, I have had to "talk down" to the lay-reader and try to explain in common sense terms why the book is good or bad. Now with this book (overpriced as it is), I finally can write a real scientific review. This book is very good, for what it is---the 5HT-2A signal transduction pathway. Yes, this is probably the main pathway that causes depression (besides HPA axis disregulation, although the 2A pathway is involved with HPA anyway). And it's also the main pathway that helps a person taking SSRI's overcome depression. <p> It explains that the 2A pathway shunts over to the noradrenaline (NA) pathway, thus providing energy and neuronal remodeling and dendrite regrowth. This is a discovery that had previously stumped researchers, because they realized that the 5HT and NA pathways must be interconnected, but they didn't know how they were. However, I think that this book brings to light an even more interesting discovery---patients with severe, suicidal depression have elevated intracellular calcium levels. Not only does the 2A pathway shunt over to the NA pathway, it also funnels into the "calcium" pathway, a complex and often redundant pathway that controls many different cellular functions, including muscle contraction. I believe that somehow the calcium pathway becomes dominant over the NA shunt, and (again, besides HPA axis disregulation) that's why patients become depressed. And certain calcium channel blockers (ex. Nimodopine) can act as antidepressants! Much more research is needed into the calcium field of brain research. The calcium pathway may also be involved in SSRI side effects, since this pathway may be stimulated in some patients, making things potentially worse, or possibly explaining why these patients are treatment-resistant. I have a chapter on this phenomenon in my book, if you care to read about it.
By: H. Leon Bradlow, Luigi Castagnetta, Luisa Massimo, Kurt Zaenker
ISBN: 1573315591
Publisher: New York Academy of Sciences
Release Date: 15 January, 2005
Bioscience book rank: 3623965
By: Johan Lennartsson
ISBN: 9155452914
Publisher: Uppsala Universitet
Release Date: May, 2002
Bioscience book rank:
By: Unknown
ISBN: B0010L5PAI
Publisher: EMD Biosciences
Release Date: 2005
Bioscience book rank:
By: David A. Jans
ISBN: 1570594376
Publisher: Landes Bioscience
Release Date: March, 1997
Bioscience book rank: 6271237
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