Mucosal tissues of various organs show similar defense mechanisms against environmental pathogens, but also organ-specific variations. The book Mucosal Immunology and Ocular Disease compares similarities and differences of mechanisms by which immunological processes may affect mucous membranes. The first part of the book introduces to the antigen handling of mucosal membranes, like antigen uptake and presentation, description of the mucosa-associated lymphoid tissue (MALT) and its afferent and efferent pathways, and also the formation of IgA, the typical mucosal immunoglobuline. The second part deals with the lacrimal gland and the conjunctiva, being recognized now as part of the MALT system. Especially the role of T-cells and the cytokine-regulation will be enlighted. It has been shown, that nasal and ocular mucosal membranes can be used for induction of tolerance. In the third part, various forms of tolerance induction will be compared. This includes presentation of work in experimental autoimmune uveitis, experimental autoimmune encephalitis, experimental rheumatitis, but also an update of ongoing clinical studies. Finally, future therapeutic ideas like recombinant vaccines will be presented. The book Mucosal Immunology and Ocular Disease summarizes the various defense mechanisms of this part of the eye in comparison to other mucous membranes and describes therapeutic strategies using mucosal membranes.
Abstracts of the presentations and papers from the 17th International Congress of Allergology and Clinical Immunology, held in Sydney, Australia, October 15-20, 2000. Proceedings also available. Softcover.
This volume offers an overview of some important aspects of immune function. V(D)J hypermutation drives the somatic evolution of antigen-reactive B lymphocytes and is necessary for the generation of protective humoral immunity. The mechanism of this hypermutation remains enigmatic, although several seemingly mutually exclusive models have been proposed. Perhaps surprisingly, this volume demonstrates that there is no consensus on the major problems in the area of somatic diversification; the same experimental data has been interpreted in different ways by various authors. This lack of consensus reveals that the field of somatic diversification, from top to bottom, is an exciting area of immunology that stubbornly keeps its secrets to itself.
Characteristic of the heat shock or stress response is the synthesis of a family of fairly well-conserved proteins of various molecular sizes - the heat-shock proteins. This volume reviews the evidence that the expression of heat-shock proteins may interact with lymphocytes that bear the gamma-delta T cell receptor and result in the initiation of immunopathology. The possibility that this subset of lymphocytes is specialized to respond to heat-shock proteins has recently generated much interest. The material presented in this volume addresses the question from a pathological perspective. Particular emphasis is placed on studies that have examined human diseases where tissue damage is quite widespread.