Related books on 'transcriptional-regulation'

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Number of products: 38
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publisher: Wiley-Liss, published: 1997-03-28
ASIN: 0471142069
EAN: 9780471142065
sales rank: 3931722
mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION

Edited by Joe B. Harford and David R. Morris

Gene expression is a process that begins with the transcription of DNA to an RNA messenger (mRNA), which is then translated into a protein. Historically, attention has been focused on the regulation of RNA synthesis (transcription); however, there is a growing recognition of and appreciation for the importance of the many regulatory mechanisms that take place after RNA synthesis has been completed.

mRNA Metabolism and Post-Transcriptional Gene Regulation is the first comprehensive overview of the various modes of gene regulation that exist post-transcriptionally. Collecting studies by some of the top researchers in the field, this volume provides both an up-to-date review of the complex "life" of an mRNA molecule and an introduction to current work on the diversity of mechanisms of post-transcriptional reactions.

Topics covered include:

  • RNA structure
  • Mammalian RNA editing
  • RNA export from the nucleus
  • The fundamentals of translation initiation
  • Control of mRNA decay in plants
  • mRNA metabolism and cancer
  • Control of mRNA stability during herpes simplex virus infection
  • Regulation of mRNA expression in HIV-1 and other complex retroviruses
  • Nucleases
  • RNA localization

A timely contribution to the understanding of genetic regulatory mechanisms, mRNA Metabolism and Post-Transcriptional Gene Regulation provides a basis from which potential therapeutic strategies may be developed. This book will be of vital interest to cell and molecular biologists at all levels, from graduate students to senior investigators, clinical researchers, and professionals in the pharmaceutical and biotechnology industries.


by: NATO
publisher: Springer, published: 1991-04
ASIN: 038751774X
EAN: 9780387517742
The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques begun in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all lev- els. This up-to-date guide discusses the post-transcriptional processes controlling and regulating gene expression in eucaryotes and procaryotes. The topics covered include transcriptional (anti)termination, mRNA stability, anti-sense RNA, translational control and translational fidelity. An understanding of these mechanisms is an essential requirement for the optimisation of gene expression in various biotechnological applications.

by: Anders Knutson
publisher: Uppsala Universitet, published: 1999-11
ASIN: 9155445438
EAN: 9789155445430
sales rank: 6860715

publisher: Betascript Publishing, published: 2010-02-20
ASIN: 6130458517
EAN: 9786130458515
High Quality Content by WIKIPEDIA articles! Post-transcriptional modification is a process in cell biology by which, in eukaryotic cells, primary transcript RNA is converted into mature RNA. A notable example is the conversion of precursor messenger RNA into mature messenger RNA (mRNA), which includes splicing and occurs prior to protein synthesis. This process is vital for the correct translation of the genomes of eukaryotes as the human primary RNA transcript that is produced as a result of transcription contains both exons, which are coding sections of the primary RNA transcript and introns, which are the non coding sections of the primary RNA transcript.

by: Jose Fernandez
publisher: LAP LAMBERT Academic Publishing, published: 2010-05-24
ASIN: 3838367642
EAN: 9783838367644
This work focuses on the identification of specific structural properties of cypin that lead to the multifunctional roles in guanine metabolism and dendrite development. We first employed phylogenetic analysis and computational structure modeling techniques to construct a three dimensional structural model of cypin. In addition, we used a combination of protein structure analysis, experimental kinetic studies, and cell culture tests to uncover novel potential ligands for cypin. We obtained a list of compounds that demonstrate higher binding affinity to GDA than does guanine. Our results provide evidence that an in silico drug discovery strategy coupled with in vitro verification can be successfully implemented to discover compounds that may have therapeutic value for the treatment of diseases and disorders where GDA activity is abnormal. The discovery of intrinsic regulators of cypin expression aids in our understanding of molecular mechanisms underlying dendritic patterning, and hence, synaptic plasticity, learning and memory.

by: American Society For Microbiology
published: 1999
ASIN: B002KIF0AU

publisher: Humana Press, published: 2010-05-19
ASIN: 1617376027
EAN: 9781617376023

by: Tolleiv Trimborn
published: 1998
ASIN: B001A87L1M

by: Shao-Cong Sun
publisher: Department of Microbiology University of Stockholm, published: 1992
ASIN: B000J0CJTQ

by: George Stomatoyannopoulos
publisher: Wiley-Liss, published: 1989-10
ASIN: 0845154028
EAN: 9780845154021
The first part of a two-volume comprehensive work on the molecular and cellular control of foetal and embryonic haemoglobins in all animal species. Part A contains an account of the transcriptional domain of human globin genes, including a review of the locus activating region and its properties.
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