Related books on 'transcriptional-regulation'
Return to life science book listNumber of products: 39
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by: Albert J. Courey publisher: Wiley-Blackwell, published: 2008-04-25 ASIN: 1405103701 EAN: 9781405103701 sales rank: 1033776 Mechanisms in Transcriptional Regulation provides a concise discussion of the fundamental concepts in transcription and its regulation.
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by: Michael Carey publisher: Cold Spring Harbor Laboratory Press, published: 2001-09 ASIN: 0879696354 EAN: 9780879696351 sales rank: 2321286 In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. "Transcriptional Regulation in Eukaryotes" aims to answer that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. Chapter 1 reviews the state-of-the-art in the RNA polymerase II transcription field; while chapters 2 to 10 are a systematic guide to the investigation of regulatory mechanisms for newly identified genes. Chapters 11 to 15 discuss approaches for synthesizing recombinant transcription factors, analyzing their binding, and deciphering their mode of action. This text reveals not only what to do but why, and how to plan properly for success. This approach should be useful for graduate students, physician-scientists, postdocs, and others entering the field, but is also valuable for established investigators undertaking in-depth studies in specific systems. Supplementing clearly written text with extensive illustrations, this text puts methods in the context of underlying theory and offers expert recommendations on experimental strategies, and encourages creativity in investigative design. Protocols for essential techniques are presented in a step by step format, together with extensive advice on troubleshooting. |
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by: Steven L. McKnight publisher: Cold Spring Harbor Laboratory Press, published: 1993-06 ASIN: 0879694254 EAN: 9780879694258 sales rank: 8374771 |
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publisher: Wiley-Liss, published: 1997-03-28 ASIN: 0471142069 EAN: 9780471142065 sales rank: 3760794 mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription of DNA to an RNA messenger (mRNA), which is then translated into a protein. Historically, attention has been focused on the regulation of RNA synthesis (transcription); however, there is a growing recognition of and appreciation for the importance of the many regulatory mechanisms that take place after RNA synthesis has been completed. mRNA Metabolism and Post-Transcriptional Gene Regulation is the first comprehensive overview of the various modes of gene regulation that exist post-transcriptionally. Collecting studies by some of the top researchers in the field, this volume provides both an up-to-date review of the complex "life" of an mRNA molecule and an introduction to current work on the diversity of mechanisms of post-transcriptional reactions. Topics covered include:
A timely contribution to the understanding of genetic regulatory mechanisms, mRNA Metabolism and Post-Transcriptional Gene Regulation provides a basis from which potential therapeutic strategies may be developed. This book will be of vital interest to cell and molecular biologists at all levels, from graduate students to senior investigators, clinical researchers, and professionals in the pharmaceutical and biotechnology industries. |
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publisher: Humana Press, published: 2007-12-14 ASIN: 1588297837 EAN: 9781588297839 sales rank: 2151287 In Post-Transcriptional Gene Regulation, renowned authors present current technical approaches to most aspects of post-transcriptional control and provide a useful and versatile laboratory bench resource. With chapters split into sections covering bioinformatics, fundamental aspects of the study of RNA biology, and techniques for specific aspects of RNA biology, the expert authors have filled the book with invaluable tricks of the trade, perfected in their state-of-the-art laboratories. This new volume from the Methods in Molecular Biology series is convinently divided into three sections. The first section presents a series of bioinformatic approaches to address the use of RNA databases and algorithms to the study of post-transcriptional regulation involving untranslated regions of transcripts. In the second section, a series of methods applicable to fundamental issues in mRNA biology are presented. These include RNA structure/function, mRNP analysis and novel methods for mRNA labeling and isolation. The third section of this volume presents methodologies to study particular aspects of post-transcriptional control. This section includes methods for the study of alternative splicing and 3’ end processing, mRNA localization, mRNA translation, mRNA stability and si/miRNA regulation. Collectively, Post-Transcriptional Gene Regulation provides the reader with a useful and versatile laboratory bench resource that will become an essential reference in the field. |
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publisher: Gulf Publishing Company, published: 1990-11 ASIN: 0943255112 EAN: 9780943255118 sales rank: 8804133 |
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by: Ganes C. Sen publisher: Landes Bioscience, published: 1997-08 ASIN: 1570595011 EAN: 9781570595011 sales rank: 8495575 Provides detailed information about the signal transduction pathways used by interferons to activate gene transcription. In addition, this book discusses how the same pathways are used by many other cytokines and thus provide a forum for cross-talk among these important biological response modifiers. Additionally, the book introduces the interferon system and describes the interferon-inducible genes whose products are responsible for the cellular actions of interferons. The nature of the interferon receptors and how the transcriptional signals are transmitted from the receptors on the cell surface to the genes in the nucleus are discussed in detail. Finally, the use of similar pathways of signal transduction by other cytokines is highlighted. |
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publisher: Company of Biologists, published: 1992-01 ASIN: 094860137X EAN: 9780948601378 |
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by: Serena Dudek publisher: Springer, published: 2007-11-12 ASIN: 0387736085 EAN: 9780387736082 sales rank: 2787915 Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function. |
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publisher: Humana Press, published: 2006-01-05 ASIN: 1588294994 EAN: 9781588294999 sales rank: 1115332 A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice. |