Related books on 'signal-transduction'
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by: Bastien D. Gomperts publisher: Academic Press, published: 2009-08-19 ASIN: 0123694418 EAN: 9780123694416 sales rank: 96614 Signal Transduction, 2e Bastien D. Gomperts University College, London, United Kingdom Ijsbrand M. Kramer University of Bordeaux, Talence, France Peter E.R. Tatham University College, London, United Kingdom Miranda Gomperts KEY FEATURES: * Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and intracellular calcium * Extensive conceptual colour artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signalling mechanisms DESCRIPTION: Signal Transduction is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. RELATED TITLES: Latchman: EUKARYOTIC TRANSCRIPTION FACTORS, 3E (1998; ISBN: 0-12-437176-0; $62.95) · In-depth insight into a subject central to cell biology and fundamental to biomedicine, including drug development · Extensive conceptual colour artwork to assist with comprehension of key topics · Special emphasis on the integration of how molecular (domain) structure determines protein function · Comprehensive referencing of both core and historical literature · Guided access and inclusion of Protein Data Bank and Swiss-Prot accession codes and URLs |
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by: Gerhard Krauss publisher: Wiley-VCH, published: 2008-04-11 ASIN: 3527313974 EAN: 9783527313976 sales rank: 294718 This all-new edition of a best-selling text has been thoroughly updated to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity, the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis is made transparent for everyone with a basic knowledge in biochemistry or molecular biology. "Valuable up-to-date information on biochemistry of signal transduction and regulation" (AFS) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research) |
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by: Gordon L. Fain publisher: Sinauer Associates, published: 2003-06-01 ASIN: 0878931716 EAN: 9780878931712 sales rank: 738017 Since the time of the ancient Greeks, we have wondered how our sense organs tell us about the world around us. During the nineteenth and twentieth centuries, the anatomy of sensory tissues was described in considerable detail, and important discoveries were made about the proteins and electrical responses of sensory receptors. The most interesting question, however, continued to elude us: how are sights and sounds and smells converted into electrical signals in a form that can be interpreted by the nervous system? This process, called sensory transduction, began to be understood only recently, as a result of the development of the techniques of patch-clamp recording and gene cloning. So much progress has now been made that it is possible to say at least in outline (but in most cases in remarkable detail) how transduction occurs for all of the major sense organs of the body. In nearly every case, the external stimulus is caught by a protein embedded in the lipid membrane of the sensory receptor. This protein then changes conformation, either directly producing an electrical signal (as for touch receptors in the skin or for hair cells in the ear and vestibular system) or triggering an enzymatic cascade and a change in the concentration of an intracellular second messenger that generates the electrical response (as in the eye and nose). Beginning with fundamental properties of ion channels and G-protein coupled signal cascades, Sensory Transduction provides a comprehensive survey of this new knowledge that, taken as a whole, represents one of the greatest achievements of modern biology and neuroscience: the unraveling of the mechanism of sensation. |
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by: Friedrich Marks publisher: Garland Science, published: 2008-11-14 ASIN: 0815342152 EAN: 9780815342151 sales rank: 195794 Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three major principles that are central to signal transduction: the protein network, its energy supply, and its evolution. It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling. It also highlights the clinical aspects of cell signaling in health and disease. |
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publisher: Humana Press, published: 2004-06-18 ASIN: 1588292452 EAN: 9781588292452 sales rank: 2335650 Carrying on the high standards of the much-acclaimed first edition, highly experienced investigators have extensively updated the first edition with many of the new approaches that have been transforming the field. Included in this new edition are readily reproducible immunoassays, fluorescence-based assays, high-throughput methods, protein modification assays, lipid second messenger assays, and chromatin immunoprecipitation techniques. Wherever possible, protocols for the assay of general classes of signal transduction components have been identified so they can be adapted to the assay of any member of that class. |
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publisher: CRC Press, published: 2005-08-04 ASIN: 0849327717 EAN: 9780849327711 sales rank: 3747408 This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation. |
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publisher: Humana Press, published: 2004-03-01 ASIN: 1588293297 EAN: 9781588293299 sales rank: 1994256 Univ. of Leicester, UK. Presents proven methods for studying G-protein-coupled receptors. Includes ligand binding, generation of model cell lines, as well as interaction and activation of G-proteins. Features step-by-step instructions. For researchers. Previous edition: c1997. |
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publisher: Wiley-Liss, published: 2003-05-30 ASIN: 0471020117 EAN: 9780471020110 sales rank: 1983724 This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable. |
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by: Aniruddha Datta publisher: CRC Press, published: 2006-11-14 ASIN: 0849371988 EAN: 9780849371981 sales rank: 599124 Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks. The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms. The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state. Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering. |
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publisher: Springer, published: 1993-12-31 ASIN: 0306445832 EAN: 9780306445835 sales rank: 8834763 |