Books on 'signal-transduction'
Total books: 581 Page 1 of 59
by: Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham
publisher: Academic Press, published: 2009-08-19
ISBN: 0123694418
sales rank: 263745
Product Description
Signal Transduction, 2e Bastien D. GompertsUniversity College, London, United KingdomIjsbrand M. KramerUniversity of Bordeaux, Talence, FrancePeter E.R. TathamUniversity College, London, United KingdomMiranda GompertsKEY FEATURES:* Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and intracellular calcium* Extensive conceptual colour artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signalling mechanismsDESCRIPTION:Signal Transduction is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.RELATED TITLES:Latchman: EUKARYOTIC TRANSCRIPTION FACTORS, 3E (1998; ISBN: 0-12-437176-0; $62.95) · In-depth insight into a subject central to cell biology and fundamental to biomedicine, including drug development· Extensive conceptual colour artwork to assist with comprehension of key topics· Special emphasis on the integration of how molecular (domain) structure determines protein function· Comprehensive referencing of both core and historical literature · Guided access and inclusion of Protein Data Bank and Swiss-Prot accession codes and URLs
Review
The authors intended this book for students and professionals. I don't fall into either group but I enjoyed it and learned from it, so I'm reviewing it for other similarly inclined non-scientists. Cell-to-cell communication is of supreme importance to multicellular organisms and so it is of interest from many points of view. For example, I am very interested in its role in evolutionary developmental biology. Other people will be more interested in hormones, nerve signaling, et al. Signal Transduction is that part of communication that happens inside the cell, between the signal and the DNA. Thus it doesn't include neurotransmitters which activate ion channels in the membrane, nor does it include steroids, which pass through the membrane and into the nucleus. Nevertheless, it covers most cell communication. In particular, there is a lot of material on G-protein-coupled receptors, which make up a majority of the receptors, and tyrosine kinase receptors, which are also plentiful. As the authors describe it, chapters 1-9 are on the "nuts and bolts" of transduction. This includes a very brief introduction to intercellular signaling molecules (such as hormones and neurotransmitters) and receptors, followed by some details about the internals, including calcium ions and phosphate exchange. In the second part, "attention is concentrated on transduction processes set in action by growth factors and adhesion molecules". There is also a short section on insulin. This part fills in the chains from the receptors to the DNA and describes the processes which regulate the chains and switch them off after they've done their jobs. The choice of emphasis in the second part allows the authors to spend some time on cancer. Failure in the growth factor pathways can cause cells to proliferate out of control; failure in cell adhesion can result in metastasis. Accordingly, there are sections on the cell cycle, the transformations of cancer cells, and apoptosis. (For more details, click above on "See all Editorial Reviews".) I said that I am not a scientist, but that doesn't mean that Signal Transduction is a book for beginners. The reader must have some experience with molecular biology diagrams in which symbols stand for molecules that are interacting with each other. Some biochemistry is required, though not a lot. The reader will need to know what amino acids, lipids, and nucleotides are. If you're unsure if this is the level for you, it might help you to click on my name above and read the "In My Own Words" part of my profile and to click on "Read all my reviews" to get some idea of what I've been reading. Signal Transduction isn't the most advanced book that I've read, but it's more advanced than most. The book jacket calls this book a "text reference" and a "valuable resource". That is the right way to see it; I have already used it to help me understand some articles on the Internet. But I also recommend that you read the book at least once all the way through, both to get the lay of the land and to enjoy this fine book. I mentioned that cell signaling is very important in evolutionary developmental biology ("Evo-Devo"). For any reader interested in that subject, I highly recommend Sean Carroll's From DNA to Diversity. If you are interested in evolution, note in Signal Transduction how enormous complexity comes about through duplication and modification of genes; indeed, whole transduction chains can be regarded as modules that are duplicated with modification. If you want to know more about what happens at the other end of the chain, at the DNA, I recommend Molecular Biology of the Gene by Watson, et al. If you want to know more about cancer, there is an excellent elementary book, Molecular Biology of Cancer, by Lauren Pecorino; this book helped prepare me for Signal Transduction.
This book is a very good introduction to the subject. Depth and breadth of coverage is in general well balanced and the abundant diagrams help understanding quite a bit. The topics choosen by the authors are informative and put together an ok picture of signaling processes. There is one main areas that have been omited and I think prevent the book from giving a "very good" (as opposed to just ok) picture of the field, namely: spatio-temporal dynamics of signaling cascades and mathematical modeling of this processes. In my opionion, understanding the spatio-temportal organization of the signaling machinery is fundamental to understand signaling and the authors do not present the subject adequately (if at all). The second failure is in the area of "systems thinking". The book fails to convey the complexity of the multiple levels of feedback and other forms of regulation that make these systems work. Spatio-temporal organization and dynamics are a fundamental part of signaling pathways and you can't get a realistic picture of what is going on without them. The field is advancing at warp speed and a new edition may be in order. Perhaps the new edition could include a couple of chapters about spatial organization and a more "holistic" view of signaling systems.
My research group used a previous edition of this text in a seminar series during our weekly group meetings as a review text. It is very good at introducing the subject matter or serving as a refresher for students. The background info adds a nice touch. The ample illustrations help convey the information for the visual learners among us.
by: Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker
publisher: Garland Science, published: 2008-11-14
ISBN: 0815342152
sales rank: 382236
Product Description
Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three major principles that are central to signal transduction: the protein network, its energy supply, and its evolution. It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling. It also highlights the clinical aspects of cell signaling in health and disease.
Review
by: James A. Hoch
publisher: Herndon, Virginia, U.S.A.: Amer Society for Microbiology, published: 1995-01-01
ISBN: 1555810896
sales rank: 1127071
Review
by: Gerhard Krauss
publisher: Wiley-VCH, published: 2008-04-11
ISBN: 3527313974
sales rank: 995795
Product Description
This all-new edition of a best-selling text has been thoroughly updated to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity, the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis is made transparent for everyone with a basic knowledge in biochemistry or molecular biology. "Valuable up-to-date information on biochemistry of signal transduction and regulation" (AFS) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research)
Review
publisher: Springer, published: 2009-12-01
ISBN: 3642021115
sales rank: 2051532
Product Description
The book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments became apparent. Given the wide range of research topics in signaling, a selection was made that not only reflects the current research interest, but also anticipates those areas that will continue to be of interest over the next several years. The health-relatedness of research was a major criterion for selection, as can be seen in the list of topics covered, such as G protein coupled receptors, growth factors, nuclear receptors, reactive oxygen and nitrogen species, the cell cycle and cancer. The emphasis is on areas of signaling research with direct clinical significance. Another field covered, one rarely highlighted in signal transduction books, is that of signaling platforms, which has been emerging as a significant research area relevant to cellular metabolism, cell proliferation, differentiation, apoptosis, neurodegenerative diseases, and cancer.
Review
publisher: Birkhäuser Basel, published: 1996-10-01
ISBN: 3764353074
sales rank: 8309993
Product Description
Provides an up-to-date, comprehensive survey of all aspects of the recognition and transduction of plant signals of both chemical and physical origin such as hormones, light, toxins, and elicitors.
Review
publisher: Springer, published: 2005-08-11
ISBN: 3540254390
sales rank: 626150
Product Description
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Review
publisher: Oxford University Press, USA, published: 1999-10-15
ISBN: 0199637202
sales rank: 1658646
Product Description
Signal transduction is an array of processes that that allow extracellular information to be converted into an intracellular message and in turn a physiological response. They are among the most highly studied processes in biology and this new edition collects some of the latest methods.
Review
publisher: Humana Press, published: 2008-12-04
ISBN: 1588299430
sales rank: 951610
Product Description
During recent years, research has greatly expanded our understanding of the sophisticated molecular network of responses which enable plants to develop, survive and propagate under a wide range of conditions. In Plant Signal Transduction: Methods and Protocols, an international panel of experts provide well-established methods vital to analyzing plant signal transduction on the molecular level. Featuring experimental procedures on several of the most popular model organisms, the volume focuses on in planta analyses and the proteins involved in signal transduction in order to aid with the establishment of laboratory techniques or the modification of the protocols for other plants. As part of the highly successful Methods in Molecular Biology? series, the chapters include brief introductions to the subject, lists of necessary materials, readily reproducible laboratory protocols, and tips on trouble-shooting and avoiding known pitfalls. Comprehensive and cutting-edge, Plant Signal Transduction: Methods and Protocols will benefit plant scientists wishing to improve their experimental approaches and delve further into this exciting and important field of study
Review
publisher: Humana Press, published: 2004-03-01
ISBN: 1588293297
sales rank: 1042837
Product Description
Univ. of Leicester, UK. Presents proven methods for studying G-protein-coupled receptors. Includes ligand binding, generation of model cell lines, as well as interaction and activation of G-proteins. Features step-by-step instructions. For researchers. Previous edition: c1997.
Review
cell culture, methods in cell biology, apoptosis, cell cycle, mitosis, signal transduction, receptor, mitochondria, ribosome, stem cell, flow cytometry
Total 581 books of 59 pages