protein-interaction books

Related books on 'protein-interaction'

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Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology)

publisher: Springer, published: 2008-08-06
ASIN: 3540728422
EAN: 9783540728429
sales rank: 559755
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Protein'Protein Interactions: Methods and Applications (Methods in Molecular Biology)

publisher: Humana Press, published: 2004-03-23
ASIN: 1588291200
EAN: 9781588291202
sales rank: 778623
A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.

Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition

publisher: Cold Spring Harbor Laboratory Press, published: 2005-10-31
ASIN: 0879697229
EAN: 9780879697228
sales rank: 1459880
This is an updated edition of a manual that provides a thorough collection of the technical and theoretical issues involved in the study of protein associations, including standard methods, biophysical approaches, and, in a final section, a collection of computational methods for integrating and analyzing interactions.

Analysis of protein interaction networks using mass spectrometry compatible techniques [An article from: Analytica Chimica Acta]

by: M. Ethier
publisher: Elsevier, published: 2006-03-30
ASIN: B000PBZYVE
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
The ability to map protein-protein interactions has grown tremendously over the last few years, making it possible to envision the mapping of whole or targeted protein interaction networks and to elucidate their temporal dynamics. The use of mass spectrometry for the study of protein complexes has proven to be an invaluable tool due to its ability to unambiguously identify proteins from a variety of biological samples. Furthermore, when affinity purification is combined with mass spectrometry analysis, the identification of multimeric protein complexes is greatly facilitated. Here, we review recent developments for the analysis of protein interaction networks by mass spectrometry and discuss the integration of different bioinformatic tools for predicting, validating, and managing interaction datasets.

Protein-Ligand Interactions (Methods and Principles in Medicinal Chemistry)

publisher: Wiley-VCH, published: 2012-06-13
ASIN: 3527329668
EAN: 9783527329663
sales rank: 3711642
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.
The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them.
With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.

DNA'Protein Interactions: Principles and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2012-07-31
ASIN: 1617371254
EAN: 9781617371257
sales rank: 11493443
Dr. Tom Moss assembles the new standard collection of cutting-edge techniques to identify key protein-DNA interactions and define their components, their manner of interaction, and their manner of function, both in the cell and in the test tube. The techniques span a wide range, from factor identification to atomic detail, and include multiple DNA footprinting analyses, including in vivo strategies, gel shift (EMSA) optimization, SELEX, surface plasmon resonance, site-specific DNA-protein crosslinking, and UV laser crosslinking. Comprehensive and broad ranging, DNA-Protein Interactions: Principles and Protocols, 2nd Edition, offers a stellar array of over 100 up-to-date and readily reproducible techniques that biochemists and molecular, cellular, and developmental biologists can use successfully today to understand DNA-protein interactions.

Protein-Ligand Interactions: Hydrodynamics and Calorimetry (Practical Approach Series)

publisher: Oxford University Press, USA, published: 2001-03-01
ASIN: 0199637466
EAN: 9780199637461
sales rank: 1026217
This book covers the principle hydrodynamic and calorimetric techniques for studying protein-ligand interactions. A ligand is an atom, molecule, or ion that can bind to a specific site on a protein, and the interactions between any protein and its ligands are fundamental for the protein to function properly. Written from a practical standpoint, this book is applicable to both academic and industrial scientists wishing to characterize protein-ligand systems by using a multi-disciplinary approach.

Computational and Structural Approaches to Drug Discovery: Ligand-Protein Interactions (RSC Biomolecular Sciences)

by: Royal Society of Chemistry
publisher: Royal Society of Chemistry, published: 2007-11-19
ASIN: 0854043659
EAN: 9780854043651
sales rank: 1279645

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials.

This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with:

A rich understanding of modern approaches to docking; A comparison and critical evaluation of state-of-the-art methods; Details on harnessing computational methods for both analysis and prediction; An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms; Critical reviews of current fragment based methods with perceptive applications to kinases.

Addressing a wide range of uses of protein structures for drug discovery the Editors have created an essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.

Small-Molecule Inhibitors of Protein-Protein Interactions (Current Topics in Microbiology and Immunology)

publisher: Springer, published: 2011-01-11
ASIN: 364217082X
EAN: 9783642170829
sales rank: 1897332
In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field

Introduction to Protein Science: Architecture, Function, and Genomics

by: Arthur M. Lesk
publisher: Oxford University Press, USA, published: 2010-05-20
ASIN: 0199541302
EAN: 9780199541300
sales rank: 225807
Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked.

Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors.

New to this edition:

* Coverage of new developments in the field, including high-throughput methods
* A new chapter on enzyme kinetics
* Extended treatments of such topics as protein evolution and the immune system
* New pedagogical features including "key points" and "Proteins in Health and Disease" boxes
* New end-of-chapter exercises, problems, and "weblems"

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	Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology) publisher: Springer, published: 2008-08-06 ASIN: 3540728422 EAN: 9783540728429 sales rank: 559755 Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
	Protein'Protein Interactions: Methods and Applications (Methods in Molecular Biology) publisher: Humana Press, published: 2004-03-23 ASIN: 1588291200 EAN: 9781588291202 sales rank: 778623 A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.
	Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition publisher: Cold Spring Harbor Laboratory Press, published: 2005-10-31 ASIN: 0879697229 EAN: 9780879697228 sales rank: 1459880 This is an updated edition of a manual that provides a thorough collection of the technical and theoretical issues involved in the study of protein associations, including standard methods, biophysical approaches, and, in a final section, a collection of computational methods for integrating and analyzing interactions.
	Analysis of protein interaction networks using mass spectrometry compatible techniques [An article from: Analytica Chimica Acta] by: M. Ethier publisher: Elsevier, published: 2006-03-30 ASIN: B000PBZYVE This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: The ability to map protein-protein interactions has grown tremendously over the last few years, making it possible to envision the mapping of whole or targeted protein interaction networks and to elucidate their temporal dynamics. The use of mass spectrometry for the study of protein complexes has proven to be an invaluable tool due to its ability to unambiguously identify proteins from a variety of biological samples. Furthermore, when affinity purification is combined with mass spectrometry analysis, the identification of multimeric protein complexes is greatly facilitated. Here, we review recent developments for the analysis of protein interaction networks by mass spectrometry and discuss the integration of different bioinformatic tools for predicting, validating, and managing interaction datasets.
	Protein-Ligand Interactions (Methods and Principles in Medicinal Chemistry) publisher: Wiley-VCH, published: 2012-06-13 ASIN: 3527329668 EAN: 9783527329663 sales rank: 3711642 Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.
	DNA'Protein Interactions: Principles and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2012-07-31 ASIN: 1617371254 EAN: 9781617371257 sales rank: 11493443 Dr. Tom Moss assembles the new standard collection of cutting-edge techniques to identify key protein-DNA interactions and define their components, their manner of interaction, and their manner of function, both in the cell and in the test tube. The techniques span a wide range, from factor identification to atomic detail, and include multiple DNA footprinting analyses, including in vivo strategies, gel shift (EMSA) optimization, SELEX, surface plasmon resonance, site-specific DNA-protein crosslinking, and UV laser crosslinking. Comprehensive and broad ranging, DNA-Protein Interactions: Principles and Protocols, 2nd Edition, offers a stellar array of over 100 up-to-date and readily reproducible techniques that biochemists and molecular, cellular, and developmental biologists can use successfully today to understand DNA-protein interactions.
	Protein-Ligand Interactions: Hydrodynamics and Calorimetry (Practical Approach Series) publisher: Oxford University Press, USA, published: 2001-03-01 ASIN: 0199637466 EAN: 9780199637461 sales rank: 1026217 This book covers the principle hydrodynamic and calorimetric techniques for studying protein-ligand interactions. A ligand is an atom, molecule, or ion that can bind to a specific site on a protein, and the interactions between any protein and its ligands are fundamental for the protein to function properly. Written from a practical standpoint, this book is applicable to both academic and industrial scientists wishing to characterize protein-ligand systems by using a multi-disciplinary approach.
	Computational and Structural Approaches to Drug Discovery: Ligand-Protein Interactions (RSC Biomolecular Sciences) by: Royal Society of Chemistry publisher: Royal Society of Chemistry, published: 2007-11-19 ASIN: 0854043659 EAN: 9780854043651 sales rank: 1279645 Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials. This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: A rich understanding of modern approaches to docking; A comparison and critical evaluation of state-of-the-art methods; Details on harnessing computational methods for both analysis and prediction; An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms; Critical reviews of current fragment based methods with perceptive applications to kinases. Addressing a wide range of uses of protein structures for drug discovery the Editors have created an essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.
	Small-Molecule Inhibitors of Protein-Protein Interactions (Current Topics in Microbiology and Immunology) publisher: Springer, published: 2011-01-11 ASIN: 364217082X EAN: 9783642170829 sales rank: 1897332 In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field
	Introduction to Protein Science: Architecture, Function, and Genomics by: Arthur M. Lesk publisher: Oxford University Press, USA, published: 2010-05-20 ASIN: 0199541302 EAN: 9780199541300 sales rank: 225807 Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked. Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors. New to this edition: * Coverage of new developments in the field, including high-throughput methods * A new chapter on enzyme kinetics * Extended treatments of such topics as protein evolution and the immune system * New pedagogical features including "key points" and "Proteins in Health and Disease" boxes * New end-of-chapter exercises, problems, and "weblems"