protein-array books

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Proteomics in cancer research: Methods and application of array-based protein profiling technologies [An article from: Analytica Chimica Acta]

by: A. Hoeben
publisher: Elsevier, published: 2006-03-30
ASIN: B000PBZYVO
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
With the human genome sequence now determined, the field of molecular medicine is moving beyond genomics to proteomics, the large-scale analysis of proteins. It is now possible to examine the expression of more than 1000 proteins using mass spectrometry technology coupled with various separation methods. Microarray technology is a new and efficient approach, for extracting relevant biomedical data and has a wide range of applications. It provides a versatile tool to study protein-protein, protein-nucleic acid, protein-lipid, enzyme-substrate and protein-drug interactions. This review paper will explore the key themes in proteomics and their application in clinical cancer research.

New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great.

by: Eric C. Westman
publisher: Touchstone, published: 2010-03-02
ASIN: 1439190275
EAN: 9781439190272
sales rank: 191

Think you know the Atkins Diet? Think Again. The New Atkins is...

Powerful:
Learn how to eat the wholesome foods that will turn your body into an amazing fat-burning machine.

Easy:
The updated and simplified program was created with you and your goals in mind.

Healthy:
Atkins is about eating delicious and healthy food -- a variety of protein, leafy greens and other vegetables, nuts, fruits, and whole grains.

Flexible:
Perfect for busy lifestyles: you can stick with Atkins at work, at home, on vacation, when you're eating out -- wherever you are.

Backed by Science:
More than 50 studies support the low-carb science behind Atkins.

But Atkins is more than just a diet. This healthy lifestyle focuses on maintenance from Day 1, ensuring that you'll not only take the weight off -- you'll keep it off for good. Featuring inspiring success stories, all-new recipes, and 24 weeks' worth of meal plans, The New Atkins for a New You offers the proven low-carb plan that has worked for millions, now totally updated and even easier than ever.

Exploration and Analysis of DNA Microarray and Protein Array Data (Wiley Series in Probability and Statistics)

by: Dhammika Amaratunga
publisher: Wiley-Interscience, published: 2003-10-21
ASIN: 0471273988
EAN: 9780471273981
sales rank: 2237151
A cutting-edge guide to the analysis of DNA microarray data
Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug’s therapeutic value–or toxicity–and cancer-spreading patterns of gene activity.
Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in both industry and academia, effectively outline all phases of this revolutionary analytical technique, from the preprocessing to the analysis stage.
Highlights of the text include:
A review of basic molecular biology, followed by an introduction to microarrays and their preparation
Chapters on processing scanned images and preprocessing microarray data
Methods for identifying differentially expressed genes in comparative microarray experiments
Discussions of gene and sample clustering and class prediction
Extension of analysis methods to protein array data
Numerous exercises for self-study as well as data sets and a useful collection of computational tools on the authors’ Web site make this important text a valuable resource for both students and professionals in the field.

Protein Arrays: Methods and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-10
ASIN: 1617374563
EAN: 9781617374562
A diverse collection of unique methodologies to synthesize and construct protein arrays for basic and clinical research in a high-throughput manner. These readily reproducible techniques can be applied to such applications as quantifying specific proteins of interest and discovering novel proteins, as well as to a variety of affinity substances, including antibodies, peptides, proteins, aptamers, and chemicals. The techniques can be used for biomarkers discovery, assay development, clinical sample testing, and building the next generation of molecular tools.

Protein Arrays, Biochips, and Proteomics (No Series)

publisher: Marcel Dekker, published: 2003-08-01
ASIN: 0824743121
EAN: 9780824743123
sales rank: 3745886
From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of past, present, and future proteomic research. Offering an abundance of figures and charts, the book compiles a wide variety of technologies and applications ranging from functionalized chip surfaces to strategies for protein expression.

Particles at Fluid Interfaces and Membranes, Volume 10: Attachment of Colloid Particles and Proteins to Interfaces and Formation of Two-Dimensional Arrays (Studies in Interface Science)

publisher: Elsevier Science, published: 2001-02-05
ASIN: 0444502343
EAN: 9780444502346
sales rank: 3294525
In the small world of micrometer to nanometer scale many natural and industrial processes include attachment of colloid particles (solid spheres, liquid droplets, gas bubbles or protein macromolecules) to fluid interfaces and their confinement in liquid films. This may lead to the appearance of lateral interactions between particles at interfaces, or between inclusions in phospholipid membranes, followed eventually by the formation of two-dimensional ordered arrays. The book is devoted to the description of such processes, their consecutive stages, and to the investigation of the underlying physico-chemical mechanisms.

The first six chapters give a concise but informative introduction to the basic knowledge in surface and colloid science, which includes both traditional concepts and some recent results. Chapters 1 and 2 are devoted to the basic theory of capillarity, kinetics of surfactant adsorption, shapes of axisymmetric fluid interfaces, contact angles and line tension. Chapters 3 and 4 present a generalization of the theory of capillarity to the case, in which the variation of the interfacial (membrane) curvature contributes to the total energy of the system. The generalized Laplace equation is applied to determine the configurations of free and adherent biological cells. Chapters 5 and 6 are focused on the role of thin liquid films and hydrodynamic factors in the attachment of solid and fluid particles to an interface. Surface forces of various physical nature are presented and their relative importance is discussed. Hydrodynamic interactions of a colloidal particle with an interface (or another particle) are also considered.
Chapters 7 to 10 are devoted to the theoretical foundation of various kinds of capillary forces. When two particles are attached to the same interface (membrane), capillary interactions, mediated by the interface or membrane, appear between them. Two major kinds of capillary interactions are described: (i) capillary immersion force related to the surface wettability (Chapter 7), (ii) capillary flotation force originating from interfacial deformations due to particle weight (Chapter 8). Special attention is paid to the theory of capillary immersion forces between particles entrapped in spherical liquid films (Chapter 9). A generalization of the theory of immersion forces allows one to describe membrane-mediated interactions between protein inclusions into a lipid bilayer (Chapter 10).

Chapter 11 is devoted to the theory of the capillary bridges and the capillary-bridge forces, whose importance has been recognized in phenomena like consolidation of granules and soils, wetting of powders, capillary condensation, long-range hydrophobic attraction, etc. The nucleation of capillary bridges is also examined.

Chapter 12 considers solid particles, which have an irregular wetting perimeter upon attachment to a fluid interface. The undulated contact line induces interfacial deformations, which engender a special lateral capillary force between the particles. The latter contributes to the dilatational and shear elastic moduli of particulate adsorption monolayers.

Chapter 13 describes how lateral capillary forces, facilitated by convective flows and some specific and non-specific interactions, can lead to the aggregation and ordering of various particles at fluid interfaces or in thin liquid films. Recent results on fabricating two-dimensional (2D) arrays from micrometer and sub-micrometer latex particles, as well as 2D crystals from proteins and protein complexes, are reviewed.

Chapter 14 presents applied aspects of the particle-surface interaction in antifoaming and defoaming. The mechanisms of antifoaming action involve as a necessary step the entering of an antifoam particle at the air-water interface. The considered mechanisms indicate the factors for control of foaminess.

Protein'Protein Interactions: Methods and Applications (Methods in Molecular Biology)

publisher: Humana Press, published: 2004-03-23
ASIN: 1588291200
EAN: 9781588291202
sales rank: 778623
A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.

Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology)

publisher: Springer, published: 2008-08-06
ASIN: 3540728422
EAN: 9783540728429
sales rank: 559755
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Protein Microarrays

by: Mark Schena
publisher: Jones and Bartlett Publishers, Inc., published: 2004-07
ASIN: 0763731277
EAN: 9780763731274
sales rank: 2527269
Protein Microarrays is one of the first books in this exciting new technology and will be an essential reference for most biologists and biotechnology professionals.

Functional Protein Microarrays in Drug Discovery (Drug Discovery Series)

publisher: CRC Press, published: 2007-03-30
ASIN: 0849398096
EAN: 9780849398094
sales rank: 4618710
As central actors in most biological functions, proteins are the subject of intense study. This has driven the development of increasingly sophisticated approaches for the study of proteins, which has extended to proteomic level methodologies. Yet currently no book has addressed all aspects of functional microarrays in a coherent and integrated fashion. Until now. Meeting the need for comprehensive and authoritative information, Functional Protein Microarrays in Drug Discovery provides an up-to-date overview of the field and the background required to actually design and develop arrays or perform and analyze array experiments.
The book is divided into five main sections that address critical aspects of the field. The first focuses on the generation of functional protein content, the first and perhaps most challenging aspect of protein microarrays. The second section describes ‘standard’ and state-of-the-art fabrication methods, focusing on issues of particular significance to functional protein microarrays. Similarly, the third section reviews current and next generation approaches to assay detection. The fourth and largest section, dedicated to applications, spans the breadth of published applications, from biomolecular interaction discovery and characterization to humoral response biomarker profiling, enzyme substrate identification and drug discovery. The final section addresses fundamental computational issues including image and data analysis as well as data visualization.
While the field’s early successes have set the stage for rapid growth, it is not without challenges. Indeed, challenges are to be expected in a fast-moving, interdisciplinary endeavor such as this, where molecular biology, protein chemistry, bioinformatics, engineering, and physical sciences intersect. As the first integrated reference for functional protein microarrays, this book helps you not only meet the challenges but also excel in your research.
X. Y. Zhu, one of the contributors to this text, was recently featured in an article in Austin's The Statesman.
Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

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	Proteomics in cancer research: Methods and application of array-based protein profiling technologies [An article from: Analytica Chimica Acta] by: A. Hoeben publisher: Elsevier, published: 2006-03-30 ASIN: B000PBZYVO This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: With the human genome sequence now determined, the field of molecular medicine is moving beyond genomics to proteomics, the large-scale analysis of proteins. It is now possible to examine the expression of more than 1000 proteins using mass spectrometry technology coupled with various separation methods. Microarray technology is a new and efficient approach, for extracting relevant biomedical data and has a wide range of applications. It provides a versatile tool to study protein-protein, protein-nucleic acid, protein-lipid, enzyme-substrate and protein-drug interactions. This review paper will explore the key themes in proteomics and their application in clinical cancer research.
	New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great. by: Eric C. Westman publisher: Touchstone, published: 2010-03-02 ASIN: 1439190275 EAN: 9781439190272 sales rank: 191 Think you know the Atkins Diet? Think Again. The New Atkins is... Powerful: Learn how to eat the wholesome foods that will turn your body into an amazing fat-burning machine. Easy: The updated and simplified program was created with you and your goals in mind. Healthy: Atkins is about eating delicious and healthy food -- a variety of protein, leafy greens and other vegetables, nuts, fruits, and whole grains. Flexible: Perfect for busy lifestyles: you can stick with Atkins at work, at home, on vacation, when you're eating out -- wherever you are. Backed by Science: More than 50 studies support the low-carb science behind Atkins. But Atkins is more than just a diet. This healthy lifestyle focuses on maintenance from Day 1, ensuring that you'll not only take the weight off -- you'll keep it off for good. Featuring inspiring success stories, all-new recipes, and 24 weeks' worth of meal plans, The New Atkins for a New You offers the proven low-carb plan that has worked for millions, now totally updated and even easier than ever.
	Exploration and Analysis of DNA Microarray and Protein Array Data (Wiley Series in Probability and Statistics) by: Dhammika Amaratunga publisher: Wiley-Interscience, published: 2003-10-21 ASIN: 0471273988 EAN: 9780471273981 sales rank: 2237151 A cutting-edge guide to the analysis of DNA microarray data Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug’s therapeutic value–or toxicity–and cancer-spreading patterns of gene activity. Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in both industry and academia, effectively outline all phases of this revolutionary analytical technique, from the preprocessing to the analysis stage. Highlights of the text include: A review of basic molecular biology, followed by an introduction to microarrays and their preparation Chapters on processing scanned images and preprocessing microarray data Methods for identifying differentially expressed genes in comparative microarray experiments Discussions of gene and sample clustering and class prediction Extension of analysis methods to protein array data Numerous exercises for self-study as well as data sets and a useful collection of computational tools on the authors’ Web site make this important text a valuable resource for both students and professionals in the field.
	Protein Arrays: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-10 ASIN: 1617374563 EAN: 9781617374562 A diverse collection of unique methodologies to synthesize and construct protein arrays for basic and clinical research in a high-throughput manner. These readily reproducible techniques can be applied to such applications as quantifying specific proteins of interest and discovering novel proteins, as well as to a variety of affinity substances, including antibodies, peptides, proteins, aptamers, and chemicals. The techniques can be used for biomarkers discovery, assay development, clinical sample testing, and building the next generation of molecular tools.
	Protein Arrays, Biochips, and Proteomics (No Series) publisher: Marcel Dekker, published: 2003-08-01 ASIN: 0824743121 EAN: 9780824743123 sales rank: 3745886 From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of past, present, and future proteomic research. Offering an abundance of figures and charts, the book compiles a wide variety of technologies and applications ranging from functionalized chip surfaces to strategies for protein expression.
	Particles at Fluid Interfaces and Membranes, Volume 10: Attachment of Colloid Particles and Proteins to Interfaces and Formation of Two-Dimensional Arrays (Studies in Interface Science) publisher: Elsevier Science, published: 2001-02-05 ASIN: 0444502343 EAN: 9780444502346 sales rank: 3294525 In the small world of micrometer to nanometer scale many natural and industrial processes include attachment of colloid particles (solid spheres, liquid droplets, gas bubbles or protein macromolecules) to fluid interfaces and their confinement in liquid films. This may lead to the appearance of lateral interactions between particles at interfaces, or between inclusions in phospholipid membranes, followed eventually by the formation of two-dimensional ordered arrays. The book is devoted to the description of such processes, their consecutive stages, and to the investigation of the underlying physico-chemical mechanisms. The first six chapters give a concise but informative introduction to the basic knowledge in surface and colloid science, which includes both traditional concepts and some recent results. Chapters 1 and 2 are devoted to the basic theory of capillarity, kinetics of surfactant adsorption, shapes of axisymmetric fluid interfaces, contact angles and line tension. Chapters 3 and 4 present a generalization of the theory of capillarity to the case, in which the variation of the interfacial (membrane) curvature contributes to the total energy of the system. The generalized Laplace equation is applied to determine the configurations of free and adherent biological cells. Chapters 5 and 6 are focused on the role of thin liquid films and hydrodynamic factors in the attachment of solid and fluid particles to an interface. Surface forces of various physical nature are presented and their relative importance is discussed. Hydrodynamic interactions of a colloidal particle with an interface (or another particle) are also considered. Chapters 7 to 10 are devoted to the theoretical foundation of various kinds of capillary forces. When two particles are attached to the same interface (membrane), capillary interactions, mediated by the interface or membrane, appear between them. Two major kinds of capillary interactions are described: (i) capillary immersion force related to the surface wettability (Chapter 7), (ii) capillary flotation force originating from interfacial deformations due to particle weight (Chapter 8). Special attention is paid to the theory of capillary immersion forces between particles entrapped in spherical liquid films (Chapter 9). A generalization of the theory of immersion forces allows one to describe membrane-mediated interactions between protein inclusions into a lipid bilayer (Chapter 10). Chapter 11 is devoted to the theory of the capillary bridges and the capillary-bridge forces, whose importance has been recognized in phenomena like consolidation of granules and soils, wetting of powders, capillary condensation, long-range hydrophobic attraction, etc. The nucleation of capillary bridges is also examined. Chapter 12 considers solid particles, which have an irregular wetting perimeter upon attachment to a fluid interface. The undulated contact line induces interfacial deformations, which engender a special lateral capillary force between the particles. The latter contributes to the dilatational and shear elastic moduli of particulate adsorption monolayers. Chapter 13 describes how lateral capillary forces, facilitated by convective flows and some specific and non-specific interactions, can lead to the aggregation and ordering of various particles at fluid interfaces or in thin liquid films. Recent results on fabricating two-dimensional (2D) arrays from micrometer and sub-micrometer latex particles, as well as 2D crystals from proteins and protein complexes, are reviewed. Chapter 14 presents applied aspects of the particle-surface interaction in antifoaming and defoaming. The mechanisms of antifoaming action involve as a necessary step the entering of an antifoam particle at the air-water interface. The considered mechanisms indicate the factors for control of foaminess.
	Protein'Protein Interactions: Methods and Applications (Methods in Molecular Biology) publisher: Humana Press, published: 2004-03-23 ASIN: 1588291200 EAN: 9781588291202 sales rank: 778623 A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.
	Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology) publisher: Springer, published: 2008-08-06 ASIN: 3540728422 EAN: 9783540728429 sales rank: 559755 Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
	Protein Microarrays by: Mark Schena publisher: Jones and Bartlett Publishers, Inc., published: 2004-07 ASIN: 0763731277 EAN: 9780763731274 sales rank: 2527269 Protein Microarrays is one of the first books in this exciting new technology and will be an essential reference for most biologists and biotechnology professionals.
	Functional Protein Microarrays in Drug Discovery (Drug Discovery Series) publisher: CRC Press, published: 2007-03-30 ASIN: 0849398096 EAN: 9780849398094 sales rank: 4618710 As central actors in most biological functions, proteins are the subject of intense study. This has driven the development of increasingly sophisticated approaches for the study of proteins, which has extended to proteomic level methodologies. Yet currently no book has addressed all aspects of functional microarrays in a coherent and integrated fashion. Until now. Meeting the need for comprehensive and authoritative information, Functional Protein Microarrays in Drug Discovery provides an up-to-date overview of the field and the background required to actually design and develop arrays or perform and analyze array experiments. The book is divided into five main sections that address critical aspects of the field. The first focuses on the generation of functional protein content, the first and perhaps most challenging aspect of protein microarrays. The second section describes ‘standard’ and state-of-the-art fabrication methods, focusing on issues of particular significance to functional protein microarrays. Similarly, the third section reviews current and next generation approaches to assay detection. The fourth and largest section, dedicated to applications, spans the breadth of published applications, from biomolecular interaction discovery and characterization to humoral response biomarker profiling, enzyme substrate identification and drug discovery. The final section addresses fundamental computational issues including image and data analysis as well as data visualization. While the field’s early successes have set the stage for rapid growth, it is not without challenges. Indeed, challenges are to be expected in a fast-moving, interdisciplinary endeavor such as this, where molecular biology, protein chemistry, bioinformatics, engineering, and physical sciences intersect. As the first integrated reference for functional protein microarrays, this book helps you not only meet the challenges but also excel in your research. X. Y. Zhu, one of the contributors to this text, was recently featured in an article in Austin's The Statesman. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.