Life science and biomedical books

Related books on 'phenotyping'

	What's Wrong With My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice by: Jacqueline N. Crawley PhD publisher: Wiley-Liss, published: 2007-03-23 ASIN: 0471471925 EAN: 9780471471929 sales rank: 657691 Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
	Phenotyping: Webster's Timeline History, 1966 - 2007 by: Icon Group International publisher: ICON Group International, Inc., published: 2010-08-17 ASIN: B0063GX55C Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Phenotyping," including when used in literature (e.g. all authors that might have Phenotyping in their name). As such, this book represents the largest compilation of timeline events associated with Phenotyping when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Phenotyping, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.
	Diagnostic Molecular Pathology: A Practical Approach Volume 1: Phenotyping and Genotyping of Inact Cells (Practical Approach Series) publisher: Oxford University Press, USA, published: 1993-01-14 ASIN: 0199632367 EAN: 9780199632367 sales rank: 10896897 Molecular techniques are now being widely applied in clinical pathology laboratories, yet many people working in these facilities have only limited experience of such procedures. Diagnostic Molecular Pathology: A Practical Approach, Volumes I and II bring together a broad spectrum of protocols relevant to the routine molecular analysis of pathological samples. Volume II demonstrates applications of molecular techniques to clinical samples, including the use of PCR, DNA sequencing, and nucleic acid hybridization for such diverse purposes as pathogen identification and forensic studies. For all the protocols there is expert guidance and detailed instruction on how to ensure accuracy and reliability, which will appeal to people working at all levels in pathology.
	High Throughput Phenotyping in Plants: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2012-07-31 ASIN: 1617799947 EAN: 9781617799945 Genetic approaches to understanding plant growth and development have always benefitted from screens that are simple, quantitative and rapid. Visual screens and morphometric analysis have yielded a plethora of interesting mutants and traits that have provided insight into complex regulatory pathways, and yet many genes within any given plant genome remain undefined. The premise underlying High Throughput Phenotyping in Plants: Methods and Protocols is that the higher the resolution of the phenotype analysis the more likely that new genes and complex interactions will be revealed. The methods described in this volume can be generally classified as quantitative profiling of cellular components, ranging from ions to small molecule metabolites and nuclear DNA, or image capture that ranges in resolution from chlorophyll fluorescence from leaves and time-lapse images of seedling shoots and roots to individual plants within a population at a field site. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, High Throughput Phenotyping in Plants: Methods and Protocols serves as an invaluable guide to plant researchers and all scientists who wish to better understand plant growth and development.
	Standards of Mouse Model Phenotyping publisher: Wiley-VCH, published: 2006-08-31 ASIN: 3527310312 EAN: 9783527310319 sales rank: 2756018 This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.
	Adipose-Derived Stem Cells: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-19 ASIN: 161737959X EAN: 9781617379598 sales rank: 1198136 During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular Biology™ series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.
	High throughput phenotyping of field-grown maize: Assessing important agronomical traits by: Loïc Winterhalter publisher: Südwestdeutscher Verlag für Hochschulschriften, published: 2012-03-20 ASIN: 3838127501 EAN: 9783838127507 Aim of the Ph.D. thesis was the detection of the canopy water mass and temperature, as well as the aerial biomass and nitrogen uptake of several tropical maize hybrids (Zea mays L.) experiencing different drought stress treatments, and also detecting the contributions of the different leaf levels of maize canopies on spectral reflectance. IR-temperature as well as spectral indices displayed a high correlation with canopy water mass and could also accurately estimate the aerial biomass and above ground nitrogen uptake of maize, while differentiating the drought stress levels and also classifying consistently the hybrids. The sensor could also detect the aerial biomass and nitrogen uptake of the lowest leaf levels and furthermore the vertical distribution of chlorophyll, aerial biomass and nitrogen uptake in maize canopies was demonstrated.
	Phenotyping and Genotyping of Patients Treated with Antidepressants: Clinical Pharmacy by: Mohamed Shams publisher: LAP LAMBERT Academic Publishing, published: 2012-04-23 ASIN: 3847312448 EAN: 9783847312444 Major depression disorder (MDD) is a pervasive mood altering illnesses affecting energy, sleep, appetite, libido and the ability to function. Optimal treatment necessitates long-term administration of antidepressants. The pharmacokinetics (PKs) of these drugs are highly variable between patients which may result from drug interactions, food, renal or hepatic impairment, age, gender, smooking or genetic polymorphism of the drug metabolizing enzymes. These high interindiviual PK variabilities are therefore prone to the occurence of sub- or supratherapeutic plasma concentrations when standard doses are administered. The two selected antidepressant drugs in this thesis were venlafaxine (V) and mirtazapine (M). The application of therapeutic drug monitoring (TDM) for phenotyping and real time PCR for genotyping was found to be a proper way of performig a high degree of pharmaceutical care to depressed patients by adjusting the dose of administered drug and thus improving therapeutic efficacy and reducing risk of adverse effects of an antidepressive pharmacotherapy with V or M.
	A phenotypic study of G protein-coupled receptor 30 mutant mice: Comprehensive phenotyping of two mouse mutant lines reveals a potential novel role of G protein-coupled receptor 30 by: Luca Meoli publisher: LAP LAMBERT Academic Publishing, published: 2012-02-07 ASIN: 3847312545 EAN: 9783847312543 Recent studies identified the G protein-coupled receptor 30 (Gpr30) as a potential new estrogen receptor. However, this finding remains still controversial and the physiological role of Gpr30 has not been clarified yet. In order to decipher the role of Gpr30 in vivo, we investigated the phenotype of a Gpr30 mutant mouse line, generated by the insertion of a beta-galactosidase-neomycin cassette into the Gpr30 open reading frame, in a primary and a secondary screen. To confirm the phenotype achieved in this first mouse line, a second one, devoid of any selection marker, was analyzed. Altogether the results achieved may contribute to a better understanding of Gpr30 function in vivo, disproving a role of Gpr30 in body weight regulation, suggesting a role in lipid and muscular metabolism, and providing evidence that Gpr30 may not be required for several estrogen-regulated physiological processes.
	Proprotein Convertases (Methods in Molecular Biology) publisher: Humana Press, published: 2011-08-02 ASIN: 1617792039 EAN: 9781617792038 sales rank: 2772981 Today, activation endoproteolysis of secretory proteins is recognized as a fundamental biological mechanism of spatial and temporal regulation of protein activity as well as of diversification of protein functions.  In Proprotein Convertases, experts in the field examine detailed methods involving proprotein convertases, the enzymes mediating this endoproteolysis, which reside within or cycle between the various compartments of the secretory pathway.  Providing a timely assessment of impact of activation/inactivation endoproteolysis in the secretory pathway, the volume offers a broader perspective on the biochemistry of the PCSKs (proprotein convertases, subtilisin/kexin-type) by exploring structural and functional analogies with bacterial subtilisin and on the enzymology of endoproteolysis itself by describing the involvement in the process of non-PCSK-type such as cathepsin L.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their specific topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Meticulous and up-to-date, Proprotein Convertases represents an instructive and useful reference book for all scientists interested in endoproteolytic activation and/or inactivation of secretory proproteins through limited proteolysis, for experts in the field and newcomers to it as well.

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