genomics books

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Bioinformatics and Functional Genomics

by: Jonathan Pevsner
publisher: Wiley-Blackwell, published: 2009-05-04
ASIN: 0470085851
EAN: 9780470085851
sales rank: 36951
The bestselling introduction to bioinformatics and functional genomics—now in an updated edition
Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.
This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:
Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions.
A completely updated companion web site, which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics
Descriptions of genome sequencing projects spanning the tree of life.
A stronger focus on how bioinformatics tools are used to understand human disease.
The book is complemented by lavish illustrations and more than 500 figures and tables—fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.
Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.
Praise for the first edition:
"...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology
"… an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering
"…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" E-Streams

Introduction to Genomics

by: Arthur Lesk
publisher: Oxford University Press, USA, published: 2012-04-26
ASIN: 0199564353
EAN: 9780199564354
sales rank: 474754
Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life?

Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genome structure and function means in terms of our future health and wellbeing.

Thoroughly revised and brought up to date, the second edition features:

* Coverage of the latest techniques and developments in the field

* Rich pedagogy: End-of-chapter exercises, web-based problems ("weblems"), and lab assignments; "Special Topic" boxes; engaging case studies new "Ethics" boxes exploring the ethical issues surrounding the study of genomics; highlighted key terms; and an end-of-book glossary

* A larger format provides greater clarity to the text and accompanying figures

* Five new chapters, including one dedicated to metabolomics

* An updated Companion Website (www.oup.com/uk/orc/bin/9780199564354) offering a range of resources, including figures from the book in electronic format, answers to end-of-chapter exercises, hints to end-of-chapter problems, a guided tour of web sites in genomics, and rotating figures

The field of genomics is enabling us to analyze life in more detail than ever before; and Introduction to Genomics tackles this conceptually challenging--and fascinating--subject in a clear, lucid way.

Introduction to Protein Science: Architecture, Function, and Genomics

by: Arthur M. Lesk
publisher: Oxford University Press, USA, published: 2010-05-20
ASIN: 0199541302
EAN: 9780199541300
sales rank: 220373
Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked.

Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors.

New to this edition:

* Coverage of new developments in the field, including high-throughput methods
* A new chapter on enzyme kinetics
* Extended treatments of such topics as protein evolution and the immune system
* New pedagogical features including "key points" and "Proteins in Health and Disease" boxes
* New end-of-chapter exercises, problems, and "weblems"

Revisiting Race in a Genomic Age (Studies in Medical Anthropology)

publisher: Rutgers University Press, published: 2008-10-10
ASIN: 081354324X
EAN: 9780813543246
sales rank: 222196
With the completion of the sequencing of the human genome in 2001, the debate over the existence of a biological basis for race has been revived. In Revisiting Race in a Genomic Age, interdisciplinary scholars join forces to examine the new social, political, and ethical concerns that are attached to how we think about emerging technologies and their impact on current conceptions of race and identity.
Essays explore a range of topics that include drug development and the production of race-based therapeutics, the ways in which genetics could contribute to future health disparities, the social implications of ancestry mapping, and the impact of emerging race and genetics research on public policy and the media.
As genetic research expands its reach, this volume takes an important step toward creating a useful interdisciplinary dialogue about its implications.

Essential Genetics: A Genomics Perspective, Fifth Edition

by: Daniel L. Hartl
publisher: Jones & Bartlett Publishers, published: 2009-12-30
ASIN: 0763773646
EAN: 9780763773649
sales rank: 93398
Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.

Human Genetics and Genomics (HUMAN GENETICS: A PROBLEM-BASED APPROACH (KORF))

by: Bruce R. Korf MD PhD
publisher: Wiley-Blackwell, published: 2006-12-25
ASIN: 0632046562
EAN: 9780632046560
sales rank: 102513
Human Genetics and Genomics, Third Edition, is the new rendition of the classic textbook Human Genetics: A Problem-Based Approach. Thoroughly updated and restructured, this brand new edition uses both a classic didactic approach to teach basic genetic concepts and a problem-based approach to demonstrate the clinical applications of genetics in medical practice. By combining both these approaches, Human Genetics and Genomics is suitable both as a textbook for genetics courses, and as a bridge into the clinical environment.
The third edition features greater emphasis on cutting edge technologies and the latest genetic issues, and a vast array of new pedagogy, such as:
Clinical snapshots covering major genetic disorders
Ethical Implications boxes discussing related ethical issues
Key summary points at the beginning of each chapter and Q&As at the end of each chapter for self-assessment
Hot topics covering new and emerging areas in genetics
Recommended reading for each chapter
A companion website at www.blackwellpublishing.com/korfgenetics

Genetics and Genomics in Nursing and Health Care

by: Theresa Beery
publisher: F.A. Davis Company, published: 2011-12-22
ASIN: 0803624883
EAN: 9780803624887
sales rank: 29783
Build the foundation you need to understand the science of genetics and its growing role in the diagnosis and treatment of diseases and disorders. Two experts in the field present the biological, psychological, and social implications of genetic influences in health care in an easy-to-read and -understand style. Inside, you ll find the thorough coverage and clinical examples you need to understand the basis of genetic inheritance, the influence of somatic and germline mutations, the multifactorial relationship of gene-environment interactions, and the foundation of ethical behavior in providing comprehensive genetic nursing care. It s perfect for both stand-alone courses or integrated into courses across the curriculum.

Computational and Statistical Approaches to Genomics

publisher: Springer, published: 2002-03-28
ASIN: 1402070233
EAN: 9781402070235
sales rank: 1850269

At the beginning of the post-sequencing era, biology must now work with the enormous amounts of quantitative data being amassed and must render complex problems in mathematical terms, with all of the computational effort that entails. This phenomenon is perhaps best exemplified by the interdisciplinary scientific activity caused by the advent of high-throughput cDNA microarray technology, which facilitates large-scale surveys of gene expression. Biologists must now work together with engineers, statisticians, computer scientists, and other specialists, in order to attain a holistic understanding of the complex relationship between genes within the genome and uncover genetic function and regulation.
Computational and Statistical Genomics aims to help researchers deal with current genomic challenges. Topics covered include:

overviews of the role of supercomputers in genomics research, the existing challenges and directions in image processing for microarray technology, and web-based tools for microarray data analysis;

approaches to the global modeling and analysis of gene regulatory networks and transcriptional control, using methods, theories, and tools from signal processing, machine learning, information theory, and control theory;

state-of-the-art tools in Boolean function theory, time-frequency analysis, pattern recognition, and unsupervised learning, applied to cancer classification, identification of biologically active sites, and visualization of gene expression data;

crucial issues associated with statistical analysis of microarray data, statistics and stochastic analysis of gene expression levels in a single cell, statistically sound design of microarray studies and experiments; and

biological and medical implications of genomics research.

This book is for any researcher, in academia and industry, in biology, computer science, statistics, or engineering, involved in genomic problems. It could also be used as an advanced level textbook in a course focusing on genomic signals, information processing, or genome biology.

Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics)

by: Sandrine Dudoit
publisher: Springer, published: 2007-12-19
ASIN: 0387493166
EAN: 9780387493169
sales rank: 1478848
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Introduction to Ecological Genomics

by: Nico M. van Straalen
publisher: Oxford University Press, USA, published: 2012-01-13
ASIN: 0199594694
EAN: 9780199594696
sales rank: 610086
The genomics revolution has expanded from its origins in molecular biology to impact upon every discipline in the life sciences, including ecology. Several lines of ecological research can now be profitably addressed using genomics technology, including issues of nutrient cycling, population structure, life-history variation, trophic interaction, stress responses, and adaptation to environmental change.

This new edition addresses a series of fundamental ecological questions: the relationship between community structure and ecological function in ecosystems; how variation in life-history patterns among species can be explained from interaction between the genome and the environment; the molecular responses to changing and toxic environmental conditions; adaptive phenotypes and their relationship to genetic variation. Each of these questions is evaluated in the light of recent advances in genomics research, paying particular attention to data obtained from sequencing and screening of environmental genomes (metagenomics), microarray-based transcription profiling, gene expression directed by signal-transduction pathways, and the analysis of genomic polymorphisms. The chapters covering these key areas are preceded by discussions of genomics methodology (including an overview of next-generation sequencing technologies) and comparative genomics, and the book concludes with a chapter on integrative approaches such as ecological control analysis. The authors also provide a comparative survey of the properties of genomes (genome size, gene families, synteny, and polymorphism) for prokaryotes as well as the main eukaryotic models.

An Introduction to Ecological Genomics incorporates a balance of plant, animal, and microbial examples, and continues to define the new and exciting field of ecological genomics.

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	Bioinformatics and Functional Genomics by: Jonathan Pevsner publisher: Wiley-Blackwell, published: 2009-05-04 ASIN: 0470085851 EAN: 9780470085851 sales rank: 36951 The bestselling introduction to bioinformatics and functional genomics—now in an updated edition Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research. This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions. A completely updated companion web site, which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics Descriptions of genome sequencing projects spanning the tree of life. A stronger focus on how bioinformatics tools are used to understand human disease. The book is complemented by lavish illustrations and more than 500 figures and tables—fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics. Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases. Praise for the first edition: "...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology "… an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering "…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" E-Streams
	Introduction to Genomics by: Arthur Lesk publisher: Oxford University Press, USA, published: 2012-04-26 ASIN: 0199564353 EAN: 9780199564354 sales rank: 474754 Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life? Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genome structure and function means in terms of our future health and wellbeing. Thoroughly revised and brought up to date, the second edition features: * Coverage of the latest techniques and developments in the field * Rich pedagogy: End-of-chapter exercises, web-based problems ("weblems"), and lab assignments; "Special Topic" boxes; engaging case studies new "Ethics" boxes exploring the ethical issues surrounding the study of genomics; highlighted key terms; and an end-of-book glossary * A larger format provides greater clarity to the text and accompanying figures * Five new chapters, including one dedicated to metabolomics * An updated Companion Website (www.oup.com/uk/orc/bin/9780199564354) offering a range of resources, including figures from the book in electronic format, answers to end-of-chapter exercises, hints to end-of-chapter problems, a guided tour of web sites in genomics, and rotating figures The field of genomics is enabling us to analyze life in more detail than ever before; and Introduction to Genomics tackles this conceptually challenging--and fascinating--subject in a clear, lucid way.
	Introduction to Protein Science: Architecture, Function, and Genomics by: Arthur M. Lesk publisher: Oxford University Press, USA, published: 2010-05-20 ASIN: 0199541302 EAN: 9780199541300 sales rank: 220373 Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked. Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors. New to this edition: * Coverage of new developments in the field, including high-throughput methods * A new chapter on enzyme kinetics * Extended treatments of such topics as protein evolution and the immune system * New pedagogical features including "key points" and "Proteins in Health and Disease" boxes * New end-of-chapter exercises, problems, and "weblems"
	Revisiting Race in a Genomic Age (Studies in Medical Anthropology) publisher: Rutgers University Press, published: 2008-10-10 ASIN: 081354324X EAN: 9780813543246 sales rank: 222196 With the completion of the sequencing of the human genome in 2001, the debate over the existence of a biological basis for race has been revived. In Revisiting Race in a Genomic Age, interdisciplinary scholars join forces to examine the new social, political, and ethical concerns that are attached to how we think about emerging technologies and their impact on current conceptions of race and identity. Essays explore a range of topics that include drug development and the production of race-based therapeutics, the ways in which genetics could contribute to future health disparities, the social implications of ancestry mapping, and the impact of emerging race and genetics research on public policy and the media. As genetic research expands its reach, this volume takes an important step toward creating a useful interdisciplinary dialogue about its implications.
	Essential Genetics: A Genomics Perspective, Fifth Edition by: Daniel L. Hartl publisher: Jones & Bartlett Publishers, published: 2009-12-30 ASIN: 0763773646 EAN: 9780763773649 sales rank: 93398 Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.
	Human Genetics and Genomics (HUMAN GENETICS: A PROBLEM-BASED APPROACH (KORF)) by: Bruce R. Korf MD PhD publisher: Wiley-Blackwell, published: 2006-12-25 ASIN: 0632046562 EAN: 9780632046560 sales rank: 102513 Human Genetics and Genomics, Third Edition, is the new rendition of the classic textbook Human Genetics: A Problem-Based Approach. Thoroughly updated and restructured, this brand new edition uses both a classic didactic approach to teach basic genetic concepts and a problem-based approach to demonstrate the clinical applications of genetics in medical practice. By combining both these approaches, Human Genetics and Genomics is suitable both as a textbook for genetics courses, and as a bridge into the clinical environment. The third edition features greater emphasis on cutting edge technologies and the latest genetic issues, and a vast array of new pedagogy, such as: Clinical snapshots covering major genetic disorders Ethical Implications boxes discussing related ethical issues Key summary points at the beginning of each chapter and Q&As at the end of each chapter for self-assessment Hot topics covering new and emerging areas in genetics Recommended reading for each chapter A companion website at www.blackwellpublishing.com/korfgenetics
	Genetics and Genomics in Nursing and Health Care by: Theresa Beery publisher: F.A. Davis Company, published: 2011-12-22 ASIN: 0803624883 EAN: 9780803624887 sales rank: 29783 Build the foundation you need to understand the science of genetics and its growing role in the diagnosis and treatment of diseases and disorders. Two experts in the field present the biological, psychological, and social implications of genetic influences in health care in an easy-to-read and -understand style. Inside, you ll find the thorough coverage and clinical examples you need to understand the basis of genetic inheritance, the influence of somatic and germline mutations, the multifactorial relationship of gene-environment interactions, and the foundation of ethical behavior in providing comprehensive genetic nursing care. It s perfect for both stand-alone courses or integrated into courses across the curriculum.
	Computational and Statistical Approaches to Genomics publisher: Springer, published: 2002-03-28 ASIN: 1402070233 EAN: 9781402070235 sales rank: 1850269 At the beginning of the post-sequencing era, biology must now work with the enormous amounts of quantitative data being amassed and must render complex problems in mathematical terms, with all of the computational effort that entails. This phenomenon is perhaps best exemplified by the interdisciplinary scientific activity caused by the advent of high-throughput cDNA microarray technology, which facilitates large-scale surveys of gene expression. Biologists must now work together with engineers, statisticians, computer scientists, and other specialists, in order to attain a holistic understanding of the complex relationship between genes within the genome and uncover genetic function and regulation. Computational and Statistical Genomics aims to help researchers deal with current genomic challenges. Topics covered include: overviews of the role of supercomputers in genomics research, the existing challenges and directions in image processing for microarray technology, and web-based tools for microarray data analysis; approaches to the global modeling and analysis of gene regulatory networks and transcriptional control, using methods, theories, and tools from signal processing, machine learning, information theory, and control theory; state-of-the-art tools in Boolean function theory, time-frequency analysis, pattern recognition, and unsupervised learning, applied to cancer classification, identification of biologically active sites, and visualization of gene expression data; crucial issues associated with statistical analysis of microarray data, statistics and stochastic analysis of gene expression levels in a single cell, statistically sound design of microarray studies and experiments; and biological and medical implications of genomics research. This book is for any researcher, in academia and industry, in biology, computer science, statistics, or engineering, involved in genomic problems. It could also be used as an advanced level textbook in a course focusing on genomic signals, information processing, or genome biology.
	Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics) by: Sandrine Dudoit publisher: Springer, published: 2007-12-19 ASIN: 0387493166 EAN: 9780387493169 sales rank: 1478848 This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
	Introduction to Ecological Genomics by: Nico M. van Straalen publisher: Oxford University Press, USA, published: 2012-01-13 ASIN: 0199594694 EAN: 9780199594696 sales rank: 610086 The genomics revolution has expanded from its origins in molecular biology to impact upon every discipline in the life sciences, including ecology. Several lines of ecological research can now be profitably addressed using genomics technology, including issues of nutrient cycling, population structure, life-history variation, trophic interaction, stress responses, and adaptation to environmental change. This new edition addresses a series of fundamental ecological questions: the relationship between community structure and ecological function in ecosystems; how variation in life-history patterns among species can be explained from interaction between the genome and the environment; the molecular responses to changing and toxic environmental conditions; adaptive phenotypes and their relationship to genetic variation. Each of these questions is evaluated in the light of recent advances in genomics research, paying particular attention to data obtained from sequencing and screening of environmental genomes (metagenomics), microarray-based transcription profiling, gene expression directed by signal-transduction pathways, and the analysis of genomic polymorphisms. The chapters covering these key areas are preceded by discussions of genomics methodology (including an overview of next-generation sequencing technologies) and comparative genomics, and the book concludes with a chapter on integrative approaches such as ecological control analysis. The authors also provide a comparative survey of the properties of genomes (genome size, gene families, synteny, and polymorphism) for prokaryotes as well as the main eukaryotic models. An Introduction to Ecological Genomics incorporates a balance of plant, animal, and microbial examples, and continues to define the new and exciting field of ecological genomics.