Life science and biomedical books

Related books on 'drug-discovery'

	Case Studies in Modern Drug Discovery and Development by: Xianhai Huang publisher: Wiley, published: 2012-05-29 ASIN: 0470601817 EAN: 9780470601815 sales rank: 135291 Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.
	Flow Cytometry in Drug Discovery and Development publisher: Wiley, published: 2011-01-11 ASIN: 0470433566 EAN: 9780470433560 sales rank: 497199 This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
	Drugs: From Discovery to Approval by: Rick Ng publisher: Wiley-Blackwell, published: 2008-12-03 ASIN: 047019510X EAN: 9780470195109 sales rank: 169038 "Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs." —Doody's Reviews, May 2009 "The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of preclinical trials." —Chemistry World, February 2009 The new edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. This second edition features many key enhancements, including Key Points, Chapter Summary, and Review Questions in each chapter, Answers to Review Questions provided in a book-end appendix, and one or two carefully selected "mini" case studies in each chapter. Richly illustrated throughout with over ninety figures and tables, this important book also includes helpful listings of current FDA and European guidelines and a special section on regulatory authority and processes in China. It is an indispensable resource for pharmaceutical industry and academic researchers, pharmaceutical managers and executives, healthcare clinicians, policymakers, regulators, and lobbyists with an interest in drug development. It is also an excellent textbook for students in pharmacy, science, and medicine courses.
	Drug Discovery and Development: Technology In Transition, 1e by: Humphrey P. Rang MB MS MA DPhil FMedSci FRS Hon FBPharmacolS publisher: Churchill Livingstone, published: 2006-01-12 ASIN: 0443064202 EAN: 9780443064203 sales rank: 350918 This title is directed primarily toward health care professionals outside the United States. An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful. Includes the new molecular techniques of drug design and development. Discusses current therapeutic needs. Covers pharmacoepidemiology and pharmacoeconomics. Edited by Humphrey Rang, who is also known throughout the world as a co-author of the enormously successful and authoritative textbook, Pharmacology, now in its fifth edition. Foreword by Daniel Vasella, CEO, Novartis International. Includes contributors from both the pharmaceutical industry and universities.
	Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods) by: Mike S. Lee publisher: Wiley, published: 2011-05-24 ASIN: 0470401966 EAN: 9780470401965 sales rank: 639637 This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
	Experiment Eleven: Dark Secrets Behind the Discovery of a Wonder Drug by: Peter Pringle publisher: Walker & Company, published: 2012-05-08 ASIN: 0802717748 EAN: 9780802717740 sales rank: 38079 In 1943, Albert Schatz, a young Rutgers College Ph.D. student, worked on a wartime project in microbiology professor Selman Waksman’s lab, searching for an antibiotic to fight infections on the front lines and at home. In his eleventh experiment on a common bacterium found in farmyard soil, Schatz discovered streptomycin, the first effective cure for tuberculosis, one of the world’s deadliest diseases. As director of Schatz’s research, Waksman took credit for the discovery, belittled Schatz’s work, and secretly enriched himself with royalties from the streptomycin patent filed by the pharmaceutical company Merck. In an unprecedented lawsuit, young Schatz sued Waksman, and was awarded the title of “co-discoverer” and a share of the royalties. But two years later, Professor Waksman alone was awarded the Nobel Prize. Schatz disappeared into academic obscurity. For the first time, acclaimed author and journalist Peter Pringle unravels the intrigues behind one of the most important discoveries in the history of medicine. The story unfolds on a tiny college campus in New Jersey, but its repercussions spread worldwide. The streptomycin patent was a breakthrough for the drug companies, overturning patent limits on products of nature and paving the way for today’s biotech world. As dozens more antibiotics were found, many from the same family as streptomycin, the drug companies created oligopolies and reaped big profits. Pringle uses firsthand accounts and archives in the United States and Europe to reveal the intensely human story behind the discovery that started a revolution in the treatment of infectious diseases and shaped the future of Big Pharma.
	The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines by: Brent R. Stockwell publisher: Columbia University Press, published: 2011-06-01 ASIN: 0231152124 EAN: 9780231152129 sales rank: 569335 After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century. Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research. Scientists such as Stockwell are now developing methods to combat these complexities—technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules—all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures. (4/4/2011)
	ADMET for Medicinal Chemists: A Practical Guide publisher: Wiley, published: 2011-03-01 ASIN: 0470484071 EAN: 9780470484074 sales rank: 469042 This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
	Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization by: Edward Kerns publisher: Academic Press, published: 2008-02-19 ASIN: 0123695201 EAN: 9780123695208 sales rank: 206276 Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint
	Fragment-based Approaches in Drug Discovery (Methods and Principles in Medicinal Chemistry) publisher: Wiley-VCH, published: 2006-10-30 ASIN: 3527312919 EAN: 9783527312917 sales rank: 984128 This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

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