Life science and biomedical books

Related books on 'dna-methylation'

	Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine (FT Press Science) by: Nicholas Wright Gillham publisher: FT Press, published: 2011-06-19 ASIN: 0137075448 EAN: 9780137075447 sales rank: 758091 This very readable overview of the rise and transformations of medical genetics and of the eugenic impulses that have been inspired by the emerging understanding of the genetic basis of many diseases and disabilities is based on a popular nonmajors course, "Social Implications of Genetics," that Gillham gave for many years at Duke University. The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.
	From Genes to Genomes: Concepts and Applications of DNA Technology by: Jeremy W. Dale publisher: Wiley, published: 2012-02-14 ASIN: 0470683856 EAN: 9780470683859 sales rank: 64277 The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.
	DNA Methylation: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-12-01 ASIN: 1617379387 EAN: 9781617379383 sales rank: 2949189 Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.
	DNA Methylation Microarrays: Experimental Design and Statistical Analysis (Chapman & Hall/CRC Biostatistics Series) by: Sun-Chong Wang publisher: Chapman and Hall/CRC, published: 2008-04-24 ASIN: 1420067273 EAN: 9781420067279 sales rank: 2265321 Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same underlying principles as gene expression microarrays, many of the analyses in the text also apply to microarray-based gene expression and histone modification (ChIP-on-chip) studies. After introducing basic statistics, the book describes wet-bench technologies that produce the data for analysis and explains how to preprocess the data to remove systematic artifacts resulting from measurement imperfections. It then explores differential methylation and genomic tiling arrays. Focusing on exploratory data analysis, the next several chapters show how cluster and network analyses can link the functions and roles of unannotated DNA elements with known ones. The book concludes by surveying the open source software (R and Bioconductor), public databases, and other online resources available for microarray research. Requiring only limited knowledge of statistics and programming, this book helps readers gain a solid understanding of the methodological foundations of DNA microarray analysis.
	DNA Methylation: Basic Mechanisms (Current Topics in Microbiology and Immunology) publisher: Springer, published: 2010-11-19 ASIN: 3642067085 EAN: 9783642067082 The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and function of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.
	DNA Methylation and Cancer Therapy (Medical Intelligence Unit) by: Moshe Szyf publisher: Springer, published: 2010-12-06 ASIN: 1441934162 EAN: 9781441934161 This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics: The molecular machinery responsible for DNA methylation and their impact on gene expression and tumorigenesis. The emerging relation between DNA methylation and chromatin modifying proteins. How the relationship between DNA methylation and chromatin modifying proteins might clarify the mechanisms and therapeutic implications of aberrant DNA methylation in cancer. Illustrations of the diagnostic potential of methylation in cancer and novel tools for using methylation profiling of cancers. The therapeutic potential of the DNA methylation machinery and novel attempts to target the DNA methylation enzymes in anticancer therapy. This book will be of interest to a wide audience, including oncologists, researchers and clinicians, and graduate students in the fields of oncology, molecular biology, and cancer therapy, as well as researchers and decision-makers in industry focusing on anticancer drugs and diagnosis.
	DNA Methylation Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2002-03-01 ASIN: 0896036189 EAN: 9780896036185 sales rank: 3238884 DNA Methylation Protocols offer a set of readily reproducible protocols of the analysis of DNA methylation and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of abnormal DNA methylation and the isolation and measurement of demethylases and related proteins.
	DNA Methylation: Approaches and Applications publisher: CRC Press, published: 2004-07-26 ASIN: 084932050X EAN: 9780849320507 sales rank: 3857354 DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book provides a balance between articles clarifying methodological details and more general review chapters that offer broad biological perspectives on DNA methylation. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing.
	DNA Methylation in Plants (Nova Biomedical) by: Boris F. Vanyushin publisher: Nova Science Pub Inc, published: 2008-10 ASIN: 1606920510 EAN: 9781606920510 sales rank: 4267199 A high degree of nuclear DNA (nDNA) methylation is a specific feature of plant genomes, they do contain 5-methylcytosine (m5C) and N6-methyl adenine (m6A). More than 30 per cent m5C is located in CNG sequences. Specific changes in DNA methylation accompany the entire life of a plant starting from seed germination up to the death programmed or induced by various agents and factors of biological or abiotic nature. Modulation of DNA methylation is one of the possible modes of the hormonal action in plant. DNA methylation in plants is species-, tissue-, organelle- and age-specific; it is involved in the control of all genetic functions including transcription, replication, DNA repair, gene transposition and cell differentiation.DNA methylation is engaged in gene silencing and parental imprinting, it controls trans genes and foreign DNA.Plants have much more complicated and sophisticated system of the multi-component and sometimes even conjugated genome (nuclear DNA) methylations compared with animals; besides, unlike animals, they have the plastids with their own unique DNA modification system that may control plastid differentiation and functioning; DNA methylation in plant mitochondria is performed in other fashion compared with it in nuclei. The nuclear DNA methylation system is controlled by three major families of cytosine DNA-methyltransferase genes, at least.In contrast to animals the inactivation of major maintenance methyltransferase MET1 (similar to animal Dnmt1) has no significant consequences for plant survival. Other plant cytosine DNA-methyltransferases have no analogs in animals. Some of them (DRM) are responsible for de novo DNA methylation including asymmetric sequences. Plant gene may be methylated at both adenine and cytosine residues; specific adenine DNA-methyltransferase was described. Adenine DNA methylation may influence cytosine modification and vice versa.Anyway, two different systems of the genome modification based on methylation of adenines and cytosines coexist in higher plants. The specific endonucleases discriminating between methylated and unmethylated DNA are present in plants. Thus, plants may have restriction-modification system. There are peculiar complicated controls for growth and development by DNA methylations in plants; they are well co-ordinated with other epigenetic signals modulating chromatin organisation.
	DNA Methylation: Development, Genetic Disease and Cancer (Current Topics in Microbiology and Immunology) publisher: Springer, published: 2006-07-28 ASIN: 3540311807 EAN: 9783540311805 sales rank: 4378646 It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.

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