genomics books

	Chemical Genomics: Reviews and Protocols (Methods in Molecular Biology)
	By: Edward D. Zanders ISBN: 1588293998 Publisher: Humana Press Release Date: 01 August, 2005 Bioscience book rank: 2610213
	Metabolic Engineering in the Post Genomic Era (Horizon Bioscience)
	By: B. Kholodenko ISBN: 0954523229 Publisher: Taylor & Francis Release Date: 12 March, 2004 Bioscience book rank: 2434145	The best place to start reading this book is the last chapter - not the back cover, which says obscurely and uninvitingly that "this book aims to help the reader understand and deal with the plasticity of living cell factories and to turn this plasticity into a desired rather than an adverse direction," and not the first chapter, which is too dense to provide the introduction that the book needs. The final chapter, in contrast, lists a set of fourteen highly pertinent questions that an engineer might ask, starting with "I have now activated the rate-limiting step in the metabolic pathway leading to my product. Why do I not see an increase in production?", and provides short practical answers together with pointers to appropriate chapters where the questions are dealt with in more detail. As there is no Preface, this is the best guide we are likely to get as to why the particular set of authors were collected together to write the book. <br /> <br />There are some excellent chapters, including Stefan Schuster's account of metabolic pathway analysis, which deals with a problem that has become especially acute now that the avalanche of new genomic data has given us a huge amount of sequence information unaccompanied by the enzyme characterization needed for making sense of it all. His own analysis of elementary flux modes provides one way of trying to deduce something about the biochemistry of an organism from the genome alone, without using the (usually missing) kinetic information, but he also mentions alternatives such as extreme pathways (discussed by Bernhard Palsson and colleagues elsewhere in the book). <br /> <br />Other good chapters include accounts of magnetic resonance methods as tools for functional genomics (Kevin Brindle), analysis of regulatory strengths in networks (Pedro Mendes and others), use of databases (Peter Karp), mathematical modelling (Wolfgang Wiechert and Ralf Takors), and so on. Some of these are individually excellent, but it is not easy to see how the whole collection hangs together to make a book, and hence not easy to guess who is likely to buy it. <br /> <br />Incidentally, the answer the editors give to the question that I quoted at the beginning is that it is rare to have a single rate-limiting step in a pathway, and even if there is one control will readily shift to a different enzyme if it is overexpressed. True enough, of course, but I wonder how convincing it is to people who have managed to ignore the message from metabolic control analysis for some three decades. As the experimental evidence (for overexpression of phosphofructokinase in fermenting yeast) has been in the literature now for more than half of that time, it might be better to start with the observation and give the explanation afterwards.
	Genomic Imprinting: An Interdisciplinary Approach (Results and Problems in Cell Differentiation)
	By: Rolf Ohlsson ISBN: 3540646671 Publisher: Springer-Verlag Telos Release Date: April, 1999 Bioscience book rank: 3062782	This is an excellent and thorough work on an interesting and important problem. All aspects of genomic imprinting are discussed in both mammalian and other systems. Well organized. If you want to learn about imprinting, this is the best place to start. Reading this book has really expanded my knowledge of this subject, and I recommend it for everyone interested in genetics.
	Functional Genomics: A Practical Approach (Practical Approach Series)
	By: Stephen P. Hunt, Rick Livesey ISBN: 0199637741 Publisher: Oxford University Press, USA Release Date: 21 December, 2000 Bioscience book rank: 1675209
	Pseudomonas: Genomics and Molecular Biology
	By: Pierre Cornelis ISBN: 1904455190 Publisher: Caister Academic Pr Release Date: January, 2008 Bioscience book rank: 173995
	Burkholderia: Molecular Microbiology and Genomics (Horizon Bioscience)
	By: Coenye&Vandamme ISBN: 1904933289 Publisher: Taylor & Francis Release Date: 02 January, 2007 Bioscience book rank: 2150911
	Genomes and Genomics of Nitrogen-fixing Organisms (Nitrogen Fixation: Origins, Applications, and Research Progress)
	By: Rafael Palacios, William E. Newton ISBN: 1402030533 Publisher: Springer Release Date: 06 April, 2005 Bioscience book rank: 2633971
	Pathogen Genomics: Impact on Human Health (Infectious Disease)
	By: Karen Joy Shaw ISBN: 1588290263 Publisher: Humana Press Release Date: 15 June, 2002 Bioscience book rank: 2518075
	Research Advances in Genetics and Genomics: Implications for Psychiatry
	By: Nancy C. Andreasen ISBN: 1585622001 Publisher: American Psychiatric Publishing, Inc. Release Date: October, 2004 Bioscience book rank: 1784262
	Apoptosis, Genomic Integrity and Cancer
	By: Julien L. Van Lancker ISBN: 0763745413 Publisher: Jones & Bartlett Publishers Release Date: 12 December, 2005 Bioscience book rank: 1842912	The book is a collection of short chapters summarizing apoptosis and cancer related proteins and genes. As a newcomer to the field (I work in cell signaling in yeast) it helped me to get the bearings to go into pubmed and other databases and ask the right questions. However, information-wise it wasn't very usefull, in part because of the shalow treatment but also because many chapters assumed a relatively high familiarity with the matter being treated. If you are a newby like me, this book won't provide you a coherent picture of the area, just some pointers to literature. If you are an expert, I don't see how would you benefit from this book. A point aside: the writting is not very good. In fact, some sections are very bad written with contradictions, incomplete, and with confusing reasoning. This book is too expensive for what it provides. I am giving it two starts because at least I was able to use as a guide to find good and more complete reviews in the existing literature. <br /> <br /> <br /> <br /> <br /> A must for graduate students and postdocs in the field. Excellent style of narration, well-written and very lucid. Upto date with current research findings. An excellent start-up for beginners in the field.